Voxel-based alterations in spontaneous brain activity among verylate-onset schizophrenia-like psychosis:A preliminary resting-state functional magnetic resonance imaging study  

作　　者：Dan-Ting Yang Ping Ji Jiao-Jiao Sun Yan-Sha Gan Shuai-Yi Guo Zhen-He Zhou Xue-Zheng Gao 

机构地区：[1]Department of Geriatric Psychiatry,The Affiliated Mental Health Center of Nanjing Medical University,Wuxi 214151,Jiangsu Province,China [2]Department of Geriatric Psychiatry,The Affiliated Mental Health Center of Jiangnan University,Wuxi 214151,Jiangsu Province,China [3]Department of Psychiatry,The Affiliated Wutaishan Hospital of Yangzhou University,Yangzhou 225003,Jiangsu Province,China [4]Department of General Psychiatry,Nantong Zilang Hospital,Nantong 226006,Jiangsu Province,China

出　　处：《World Journal of Psychiatry》2025年第3期66-77,共12页世界精神病学杂志(英文)

基　　金：Supported by Wuxi Municipal Health Commission Major Project,No.202107;and Wuxi Taihu Talent Project,No.WXTTP 2021.

摘　　要：BACKGROUND Very late-onset schizophrenia-like psychosis(VLOSLP)is a subtype of schizophrenia spectrum disorders in which individuals experience psychotic symptoms for the first time after the age of 60.The incidence of VLOSLP shows a linear relationship with increasing age.However,no studies have reported alterations in spontaneous brain activity among VLOSLP patients and their correlation with cognitive function and clinical symptoms.AIM To explore VLOSLP brain activity and correlations with cognitive function and clinical symptoms using resting-state functional magnetic resonance imaging.METHODS This study included 33 VLOSLP patients and 34 healthy controls.The cognitive assessment utilized the Mini Mental State Examination,Montreal Cognitive Assessment,and the Repeatable Battery for the Assessment of Neuropsychological Status(RBANS).Clinical characteristic acquisition was performed via the Positive and Negative Syndrome Scale(PANSS).All participants were scanned via resting-state functional magnetic resonance imaging,and the data were processed using amplitude of low-frequency fluctuations(ALFF),fractional ALFF(fALFF),regional homogeneity,and voxelmirrored homotopic connectivity(VMHC).RESULTS The VLOSLP group presented decreased ALFF values in the left cuneus,right precuneus,right precentral gyrus,and left paracentral lobule;increased fALFF values in the left caudate nucleus;decreased fALFF values in the right calcarine fissure and surrounding cortex(CAL)and right precuneus;increased regional homogeneity values in the right putamen;and decreased VMHC values in the bilateral CAL,bilateral superior temporal gyrus,and bilateral cuneus.In the VLOSLP group,ALFF values in the right precuneus were negatively correlated with Mini Mental State Examination score and PANSS positive subscale score,and VMHC values in the bilateral CAL were negatively correlated with the RBANS total score,RBANS delayed memory score,and PANSS positive subscale score.CONCLUSION The changes of brain activity in VLOSLP are concentrated in the r

关 键 词：Very-late-onset schizophrenia-like psychosis SCHIZOPHRENIA Resting-state functional magnetic resonance imaging Amplitude of low-frequency fluctuations Fractional amplitude of low-frequency fluctuations Regional homogeneity Voxelmirrored homotopic connectivity 

分 类 号：R742.1[医药卫生—神经病学与精神病学]