Using the THINC-integrated tool to compare the characteristics of cognitive dysfunction in patients with unipolar and bipolar depression  

作　　者：Na Zhu Qi Zhang Jia Huang Jie Tong Heng-Fen Gong Ming-Huan Zhu Wei Lu Jie Zhang Xi-Rong Sun 

机构地区：[1]Clinical Research Center for Mental Disorders,Shanghai Pudong New Area Mental Health Center,School of Medicine,Tongji University,Shanghai 200124,China [2]Clinical Research Center,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China

出　　处：《World Journal of Psychiatry》2025年第3期175-185,共11页世界精神病学杂志(英文)

基　　金：Supported by Science and Technology Development Fund of Shanghai Pudong New Area,No.PKJ2023-Y20;Key Discipline Construction Fund of the Shanghai Pudong New Area Municipal Commission of Health and Family Planning,No.PWZxk2022-18;Pudong New Area Construction Project of National Traditional Chinese Medicine Development Comprehensive Reform Pilot Zone,No.PDZY-2022-0501.

摘　　要：BACKGROUND Major depressive disorder(MDD)and bipolar depression(BD-D)are both intricate,enduring,and profound psychiatric conditions characterized primarily by depressive episodes and cognitive dysfunction.However,distinguishing the characteristics and influencing factors of cognitive impairment in unipolar and BD-D is crucial for identification and intervention.AIM To compare neurocognitive characteristics and investigate associations between cognitive function and clinical features in unipolar and BD-D.METHODS The THINC-integrated tool(THINC-it)as a cognitive assessment tool was applied to 295 individuals:75 patients with depressive disorders(MDD),120 individuals with BD-D,and 100 healthy controls.The Hamilton Depression Scale-17(HAMD),Hamilton Anxiety Scale-14(HAMA),and Pittsburgh Sleep Quality Index(PSQI)were employed to assess depression,anxiety,and sleep.Neurocognitive function characteristics and the relationships between cognitive impairment and general clinical attributes were analyzed.RESULTS There were no statistically significant differences in the overall THINC-it with each objective subscale.However,the subjective subscale(Perceived Deficits Questionnaire for Depression-5-item)showed significant differences between MDD and BD-D(P<0.001).Linear regression analyses were explored to determine associations.Age,years of education,age at onset,and HAMD were significantly co-associated with the overall THINC-it and each subscale in both MDD and BD-D(P<0.05).Furthermore,years of education showed a positive correlation with objective cognitive impairment(e.g.,Codebreaker,Trails)(P<0.05).There was a notable difference in that the number of depressive episodes,disease duration,hospitalizations,HAMA,and PSQI were significantly associated with the overall THINC-it with each subscale between MDD and BD-D(P<0.05).CONCLUSION Although both unipolar and BD-D showed similar objective cognitive impairments,there was a significant difference in subjective cognitive impairment.Our findings suggest that factors like age,y

关 键 词：Unipolar and bipolar depression THINC-integrated tool Objective cognitive impairments Subjective cognitive impairment Depression Influencing factor 

分 类 号：R74[医药卫生—神经病学与精神病学]