Mood symptoms,cognitive function,and changes of brain hemodynamics in patients with COVID-19:A functional near-infrared spectroscopy study  

作　　者：Wen-Jin Ma Ruo-Chao Yuan Zi-Yu Peng Qian Wu Manal Al-Matary Hui-Shu Yang Peng Cheng Guang-Ju Zhao Chao-Chao Lu Yue-Xin Zhang Jia-Kun Hong Wei-Hui Li 

机构地区：[1]Department of Psychiatry,National Clinical Research Center for Mental Disorders,National Center for Mental Disorders,The Second Xiangya Hospital of Central South University,Changsha 410011,Hunan Province,China [2]Research Center of Educational Neuroscience,School of Educational Science,Huazhong University of Science and Technology,Wuhan 430074,Hubei Province,China [3]Department of Education,Hunan Normal University,Changsha 410081,Hunan Province,China [4]Guigang Medical District of No.923 Hospital,PLA Joint Logistics Support Force,Guigang 537000,Guangxi Zhuang Autonomous Region,China

出　　处：《World Journal of Psychiatry》2025年第3期193-215,共23页世界精神病学杂志(英文)

基　　金：Supported by Hunan Provincial Scientific Research Plan Project of Traditional Chinese Medicine;National Natural Science Foundation of China,No.82371521;Special Tasks for the Construction of Hunan Innovative Province,No.2023SK4002.

摘　　要：BACKGROUND Many patients with coronavirus disease 2019(COVID-19)may experience emotional issues and cognitive impairment.However,it remains unclear whether the brain mediates the impact of COVID-19 on the emergence of psychopathological symptoms.It remains unclear whether anxiety and depression are caused by stressors or viral infection.AIM To use functional near-infrared spectroscopy(fNIRS)to detect cortical hemodynamic changes in patients with COVID-19 and their relationship with mental symptoms(mainly depression and anxiety),to investigate whether COVID-19 causes these changes by affecting brain function.METHODS A total of 58 subjects,comprising 29 patients with first acute COVID-19 infection and 29 healthy controls without COVID-19 infection and without anxiety or depression were recruited.Then cortical activation during the performance of the verbal fluency test(VFT)and brain connectivity during the resting state(rs)were evaluated by 53-channel fNIRS.For the COVID-19-infected group,Patient Health Questionnaire-9(PHQ-9)and General Anxiety Disorder-7(GAD-7)were used to assess the emotional state before fNIRS measures.RESULTS For the rs,compared to the uninfected group,the infected group exhibited lower rs functional connectivity(FC)in the dorsolateral prefrontal cortex(DLPFC),which was correlated with both the PHQ score and GAD score.During the VFT,the infected group exhibited significantly lower cortical activation than the uninfected group in both Broca-left and Broca-right.Besides,the integral value in the DLPFC-L showed a significant negative correlation with the PHQ-9 score during the VFT in the infected group.CONCLUSION There were significant differences in the bilateral Broca area and DLPFC between the COVID-19-infected and uninfected groups,which may be the reason why COVID-19 infection impairs cognitive function and language function and leads to psychiatric symptoms.In addition,the rsFC in patients with COVID-19 was positively correlated with the severity of depression and anxiety,which may be relate

关 键 词：COVID-19 DEPRESSION ANXIETY Cognitive function Functional near-infrared spectroscopy Verbal fluency test 

分 类 号：R749.16[医药卫生—神经病学与精神病学]