Sex and age differences in depression and anxiety networks among adolescents with idiopathic scoliosis:A network analysis  

作　　者：Shu-Wen Dong Lei Yang Yi-Fan Lin Li-Wen Yang Dan Li Li-Wan Zhu Cai-Yun Zhang Yan-Zhi Li Wan-Xin Wang Ci-Yong Lu Bin Yan 

机构地区：[1]Department of Medical Statistics and Epidemiology,School of Public Health,Sun Yat-Sen University,Guangzhou 510080,Guangdong Province,China [2]Department of Spine Surgery,The First Affiliated Hospital of Shenzhen University,Shenzhen 518035,Guangdong Province,China [3]Medical Innovation Technology Transformation Center,Shenzhen Second People’s Hospital,Shenzhen 518035,Guangdong Province,China [4]Department of Spine Surgery,The First Affiliated Hospital,Shenzhen University,Shenzhen Second People’s Hospital,Shenzhen 518035,Guangdong Province,China

出　　处：《World Journal of Psychiatry》2025年第3期261-271,共11页世界精神病学杂志(英文)

基　　金：Supported by The Sanming Project of Medicine in Shenzhen,No.SZSM202211003;Shenzhen-Hong Kong Jointly Funded Project,Shenzhen Science and Technology Program,No.SGDX20230116093645007;Shenzhen Second People's Hospital Clinical Project,No.20243357003;Shenzhen Medical Research Fund,No.B2303005.

摘　　要：BACKGROUND Depression and anxiety are prevalent psychological challenges among patients with adolescent idiopathic scoliosis(AIS),affecting individuals across both sex and age groups.AIM To explore the network structure of depression and anxiety symptoms,with a focus on identifying differences at the symptom level between sex and age subgroups.METHODS A total of 1955 participants diagnosed with AIS aged 10-18 years were assessed using the Patient Health Questionnaire Depression Scale(PHO-9)and the Generalized Anxiety Disorder Scale(GAD-7),and 765 patients exhibiting PHQ-9 or GAD-7 scores ≥ 5 were enrolled in our study. Network analysis and network comparison tests were utilized toconstruct and compare the depression-anxiety symptoms networks among sex and age subgroups.RESULTSThe results revealed GAD3 “Excessive worry” and PHQ2 “Sad mood” were the most significant central symptomsin all subgroups, while “Sad mood” had higher strength than “Excessive worry” in the lower age group. In thenetwork comparisons, the female network exhibited tighter connectivity, especially on GAD6 “Irritability” andGAD2 “Uncontrollable worry”, while only PHQ3 “Sleep” and PHQ9 “Suicidal ideation” had differences at thelocal level in the lower age group.CONCLUSIONSeveral interventions targeting excessive worry and sad mood could reduce the risk of depression and anxietysymptoms in the AIS population. Furthermore, specific anxiety symptoms in females, along with sleep disturbancesand suicidal ideation in the lower age group, should be addressed at an early stage to prevent significantdisruptions in mental health trajectories.

关 键 词：Adolescent idiopathic scoliosis Network analysis Depression and anxiety symptoms Age difference Sex difference 

分 类 号：R749.4[医药卫生—神经病学与精神病学]