Impact of miR-214-5p and miR-21-5p from hypoxic endometrial exosomes on human umbilical cord mesen-chymal stem cell function  

作　　者：Jin-Wei Zhang 

机构地区：[1]State Key Laboratory of Chemical Biology,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China [2]Institute of Biomedical and Clinical Sciences,Medical School,Faculty of Health and Life Sciences,University of Exeter,Exeter EX44PS,United Kingdom

出　　处：《World Journal of Stem Cells》2025年第2期137-140,共4页世界干细胞杂志(英文)

基　　金：the National Natural Science Foundation of China,No.82170406 and No.81970238;the Royal Society United Kingdom,No.IEC\NSFC\201094.

摘　　要：Exosomes derived from hypoxic endometrial epithelial cells are pivotal in cellular communication and tissue repair,offering new perspectives on reproductive health.This manuscript highlights the study by Zhang et al,which investigates the effects of miR-214-5p and miR-21-5p in hypoxic cell-derived exosomes on human umbilical cord mesenchymal stem cells.The study reveals that low levels of these microRNAs activate the signal transducer and activator of transcription 3 signaling pathway,enhancing human umbilical cord mesenchymal stem cell migration and differentiation.These findings provide novel insights into therapeutic strategies for improving endometrial health and addressing infertility linked to thin endometrium.

关 键 词：MiR-214-5p MiR-21-5p Hypoxic endometrial epithelial cells EXOSOMES Human umbilical cord mesenchymal stem cells Signal transducer and activator of transcription 3 signaling Thin endometrium INFERTILITY 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]