Antiphospholipid syndrome in pregnancy:A comprehensive review  

作　　者：Prosper Akankwasa Jackson Kakooza John Katongole Esther Namutosi Catherine Lewis Emmanuel Okurut 

机构地区：[1]Department of Obstetrics and Gynecology,Kampala International University Western Campus,Ishaka Bushenyi,Uganda [2]Department of Surgery,Kampala International University Western Campus,Ishaka Bushenyi,Uganda [3]Department of Surgery,St.Joseph's Kitovu Hospital,Masaka,Uganda [4]Department of Surgery,Quillen College of Medicine,East Tennessee State University,Johnson City,TN 37614,United States

出　　处：《World Journal of Rheumatology》2025年第2期1-11,共11页世界风湿病学杂志(英文)

摘　　要：Antiphospholipid syndrome(APS)is a systemic autoimmune disorder characterized by the presence of antiphospholipid antibodies and is associated with thrombotic events and pregnancy complications.The classification and management of APS has evolved over time.The classification criteria for APS include laboratory,macrovascular,microvascular,obstetric,cardiac,and hematologic domains.Management focuses on prevention of thrombotic events and/or anticoagulation as the primary treatment for thrombosis.Postpartum and long-term thromboprophylaxis after delivery are recommended to reduce the risk of thrombotic events.Despite these recommendations,optimal anticoagulation agents and intensity of treatment are still topics of debate.Further research is needed to understand the pathophysiology of APS and improve its management during pregnancy.In this review,we discuss the classification and pathophysiology of APS.Current treatment options and clinical trials are also discussed.

关 键 词：Antiphospholipid syndrome Pregnancy complications THROMBOSIS ANTICOAGULATION Autoimmune disorder 

分 类 号：R714[医药卫生—妇产科学]