Gilbert’s syndrome:The good,the bad and the ugly  

作　　者：Arjuna Priyadarsin De Silva Nilushi Nuwanshika Madunil Anuk Niriella Hithanadura Janaka de Silva 

机构地区：[1]Department of Medicine,Faculty of Medicine,University of Kelaniya,Ragama 11010,Sri Lanka

出　　处：《World Journal of Hepatology》2025年第2期47-53,共7页世界肝病学杂志(英文)

摘　　要：Gilbert’s syndrome(GS)is a common hereditary condition characterized by mild increases in serum bilirubin levels due to inherited defects in bilirubin metabolism.This review,based on peer-reviewed articles spanning from 1977 to January 2024 and sourced through the PubMed platform,provides an overview of current knowledge regarding GS.Early studies primarily focused on defining the clinical and genetic characteristics of the syndrome.More recent research has delved into the genetic mechanisms underlying the reduced expression of bilirubin UDP-glucuronosyltransferase,significantly enhancing our understanding of the pathogenesis of GS.Recent studies have also investigated clinical implications of GS,including its association with metabolic associated steatotic liver disease,cardiovascular disease,mental health and mortality risk,highlighting the complex interplay between genetic factors,bilirubin metabolism,and clinical outcomes.

关 键 词：Gilbert’s syndrome Genetic variations Protective effects Drug metabolism Clinical implications 

分 类 号：R575[医药卫生—消化系统]