Association between Helicobacter pylori infection and metabolic dysfunction-associated steatohepatitis:From an analysis of a population-based study  

作　　者：Cheng-Fei Zhao 

机构地区：[1]School of Pharmacy and Medical Technology,Putian University,Putian 351100,Fujian Province,China [2]Key Laboratory of Pharmaceutical Analysis and Laboratory Medicine in University of Fujian Province,Putian University,Putian 351100,Fujian Province,China

出　　处：《World Journal of Hepatology》2025年第2期305-309,共5页世界肝病学杂志(英文)

基　　金：Supported by Scientific Research Project of Putian University,No.2022059.

摘　　要：The growing global burden of metabolic dysfunction-associated steatohepatitis(MASH)demands a deeper understanding of its underlying mechanisms and risk factors.Recent studies,such as the large population-based case-control analysis by Abdel-Razeq et al,suggest a significant association between Helicobacter pylori(H.pylori)infection and an increased risk of developing MASH.This study provides compelling data supporting this association,even after adjusting for confounders such as obesity,diabetes,and hyperlipidemia.However,the complexity of this relationship remains unresolved,requiring further investigation into the biological,genetic,and environmental pathways that connect these two conditions.This article critically reviews the study’s findings and identifies its limitations,offering innovative research directions for the future.Key areas of focus include integrating genomic and microbiome analyses,exploring the impact of H.pylori eradication on MASH progression,studying molecular mechanisms at the intersection of infection and liver disease,and developing personalized therapeutic strategies.

关 键 词：Helicobacter pylori infection Metabolic dysfunction-associated steatohepatitis Metabolic dysfunction-associated steatotic liver disease Non-alcoholic fatty liver disease Innovative research directions 

分 类 号：R575.5[医药卫生—消化系统]