Multiple primary cancers with gastrointestinal malignant tumors as the first manifestation:Three case reports and review of literature  

作　　者：Xin-Ran Bi Shuang-Yan Zhao Yu-Qi Ma Xiao-Yu Duan Ting-Ting Hu Lian-Zhu Bi Hong-Yi Cai 

机构地区：[1]The First Clinical Medical College of Gansu University of Traditional Chinese Medicine,Lanzhou 730000,Gansu Province,China [2]Department of Radiotherapy Center,Gansu Provincial Hospital,Lanzhou 730000,Gansu Province,China [3]Department of Gastrointestinal Surgery,Gansu Provincial Hospital,Lanzhou 730000,Gansu Province,China [4]Department of Neurology,Hospital of Fengnan District,Tangshan 063300,Hebei Province,China

出　　处：《World Journal of Gastroenterology》2025年第8期130-139,共10页世界胃肠病学杂志(英文)

基　　金：Supported by Gansu Provincial Natural Science Foundation,No.21JR1RA010;In-Hospital Research Fund of Gansu Provincial Hospital,No.23GSSYD-5.

摘　　要：BACKGROUND The incidence of malignant gastrointestinal(GI)tumors is increasing,and advancements in medical care have significantly improved patient survival rates.As a result,the number of cases involving multiple primary cancers(MPC)has also increased.The rarity of MPC and the absence of sensitive and specific dia-gnostic markers often lead to missed or incorrect diagnoses.It is,therefore,of vital importance to improve the vigilance of clinicians and the accurate diagnosis of this disease.Patients with GI malignancies face a higher relative risk of deve-loping additional primary malignant tumors compared to those with other systemic tumors.Vigilant monitoring and follow-up are crucial,especially for high-risk groups,which include older adults,men,those with addictions to alcohol and tobacco,those with a family history of tumors,and those who have undergone radiotherapy.CASE SUMMARY In this article,we report three cases of MPC,each involving malignant tumors of the GI tract as the initial primary carcinoma,offering insights that may aid in effectively managing similar cases.CONCLUSION Patients with GI malignancies face a higher MPC risk.Developing screening and follow-up protocols may enhance detection and treatment outcomes.

关 键 词：Multiple primary cancer Gastrointestinal tract SYNCHRONOUS METACHRONOUS Case report 

分 类 号：R73[医药卫生—肿瘤]