Role of Helicobacter pylori infection and the risk of cholelithiasis  

作　　者：Nicolò Fabbri Salvatore Greco Antonio Pesce Francesco Virgilio Danila Romeo Carlo V Feo 

机构地区：[1]Unit of General Surgery,Local Health Agency of Ferrara,Ferrara 44100,Emilia-Romagna,Italy [2]Unit of Internal Medicine,Local Health Agency of Ferrara,Ferrara 44100,Emilia-Romagna,Italy [3]Department of Morphology,Surgery,and Experimental Medicine,University of Ferrara,Ferrara 44100,Emilia-Romagna,Italy [4]Unit of Hepato-Biliary Surgery,IRCCS San Raffaele Hospital,Milan 20132,Lombardy,Italy [5]Local Health Agency of Ferrara,Ferrara 44100,Emilia-Romagna,Italy

出　　处：《World Journal of Gastroenterology》2025年第8期152-154,共3页世界胃肠病学杂志(英文)

摘　　要：This article aims to deepen the understanding of the role of Helicobacter pylori(H.pylori)infection in the development of cholelithiasis,initiated by the article by Yao et al,who investigated the potential link between H.pylori infection and the development of cholelithiasis through a multicenter retrospective study on an Asian population of over 70000 participants.They also performed a compre-hensive analysis of previously published studies on H.pylori and cholelithiasis,finding a positive association therein[odds ratio(OR)=1.103,P=0.049].Patients positive for H.pylori also had lower levels of total and direct bilirubin,but higher levels of total cholesterol and low-density lipoprotein cholesterol compared to uninfected patients(P<0.05).Cohort studies have confirmed that H.pylori is a risk factor for cholelithiasis(P<0.0001),and aggregate analyses of case-control and cross-sectional studies have shown a positive association between H.pylori and cholelithiasis in Asia(OR=1.599,P=0.034),but not in Europe(OR=1.277,P=0.246).Moreover,H.pylori appears to be related to a higher ratio of choledocho-lithiasis/cholecystolithiasis(OR=3.321,P=0.033).The authors conclude that H.pylori infection is positively correlated with cholelithiasis,particularly with the choledocholithiasis phenotype,especially in Asia,and it is potentially related to bilirubin and cholesterol metabolism.

关 键 词：Helicobacter pylori Helicobacter pylori infection CHOLELITHIASIS Proton pump inhibitors CHOLEDOCHOLITHIASIS 

分 类 号：R57[医药卫生—消化系统]