Unexpected contralateral axillary lymph node metastasis without ipsilateral involvement in triple-negative breast cancer:A case report and review of literature  

作　　者：Yun-Ting Lin Zhi-Jie Hong Guo-Shiou Liao Ming-Shen Dai Tai-Kuang Chao Wen-Chiuan Tsai Yu-Kai Sung Chuang-Hsin Chiu Cheng-Kuang Chang Jyh-Cherng Yu 

机构地区：[1]Department of General Medicine,Tri Service General Hospital,National Defense Medical Center,Taipei 114,Taiwan [2]Division of Traumatology,Department of Surgery,Tri-Service General Hospital,National Defense Medical Center,Taipei 114,Taiwan [3]Division of General Surgery,Department of Surgery,Tri Service General Hospital,National Defense Medical Center,Taipei 114,Taiwan [4]Division of Hematology/Oncology,Department of Internal Medicine,National Defense Medical Center,Taipei 114,Taiwan [5]Department of Pathology and Parasitology,Tri-Service General Hospital,National Defense Medical Center,Taipei 114,Taiwan [6]Department of Pathology,National Defense Medical Center,Taipei 114,Taiwan [7]Department of Nuclear Medicine,Tri-Service General Hospital,National Defense Medical Center,Taipei 114,Taiwan [8]Department of Radiology,Tri-Service General Hospital,National Defense Medical Center,Taipei 114,Taiwan

出　　处：《World Journal of Clinical Cases》2025年第18期85-93,共9页世界临床病例杂志(英文)

摘　　要：BACKGROUND Breast cancer is a leading cause of cancer-related mortality among women worldwide,with invasive ductal carcinoma(IDC)being the most prevalent subtype.Lymph node metastasis is the primary prognostic indicator,typically evaluated via biopsy of the ipsilateral sentinel or axillary lymph nodes.Contralateral axillary metastasis(CAM)without ipsilateral involvement is exceedingly rare,particularly in early-stage breast cancer.This report presents a case of CAM in a patient with triple-negative breast cancer(TNBC),underscoring diagnostic and therapeutic complexities.CASE SUMMARY A 73-year-old female presented with left-sided early-stage IDC in February 2023.Despite a modified radical mastectomy and pathologically negative ipsilateral lymph nodes,a postoperative positron emission tomography(PET)scan detected fluorodeoxyglucose-avid nodes in the contralateral axilla.Biopsy confirmed metastatic ductal carcinoma with triple-negative status,resulting in an upstaged diagnosis of metastatic breast cancer,stage IV,M1.The patient underwent six cycles of adjuvant chemotherapy,with follow-up PET imaging showing regression of the contralateral lesion.This case highlights the importance of advanced imaging in TNBC for precise staging and treatment optimization.CONCLUSION This case highlights the aggressive nature of TNBC and the need for advanced imaging to ensure accurate staging and effective management.

关 键 词：Triple negative breast neoplasms Invasive ductal carcinoma Lymphatic metastasis Contralateral axillary metastasis Positron-emission tomography Case report 

分 类 号：R73[医药卫生—肿瘤]