Why should lymphocytes immune profile matter in sepsis?  

作　　者：Wagner Nedel Lílian R Henrique Luis Valmor Portela 

机构地区：[1]Department of Intensive Care Unit,Conceição Hospital Group,Porto Alegre 91350200,Brazil [2]Department of Biochemistry,Institute of Basic Health Sciences,Federal University of Rio Grande do Sul,Porto Alegre 90035-003,Brazil

出　　处：《World Journal of Critical Care Medicine》2025年第2期18-26,共9页世界重症医学杂志(英文)

摘　　要：The global incidence of critical illness has been steadily increasing,resulting in higher mortality rates thereby presenting substantial challenges for clinical mana-gement.Among these conditions,sepsis stands out as the leading cause of critical illness,underscoring the urgent need for continued research to enhance patient care and deepen our understanding of its complex pathophysiology.Lympho-cytes play a pivotal role in both innate and adaptive immune responses,acting as key regulators of the balance between pro-inflammatory and anti-inflam-matory processes to preserve immune homeostasis.In the context of sepsis,an impaired immunity has been associated with disrupted lymphocytic metabolic activity,persistent pro-inflammatory state,and subsequent immunosuppression.These disruptions not only impair pathogen clearance but also predispose pati-ents to secondary infections and hinder recovery,highlighting the importance of targeting lymphocyte dysfunction in sepsis management.Moreover,studies have identified absolute lymphocyte counts and derived parameters as promising clinical biomarkers for prognostic assessment and therapeutic decision-making.In particular,neutrophil-to-lymphocyte ratio,and lymphopenia have gained reco-gnition in the literature as a critical prognostic markers and therapeutic target in the management of sepsis.This review aims to elucidate the multifaceted role of lymphocytes in pathophysiology,with a focus on recent advancements in their use as biomarkers and key findings in this evolving field.

关 键 词：LYMPHOCYTES Neutrophil-to-lymphocyte ratio SEPSIS Septic shock Chronic critical illness Persistent inflammation immunosuppression and catabolism syndrome 

分 类 号：R73[医药卫生—肿瘤]