Assessment of new pathological markers in early stage colon cancer:Insights and limitations  

作　　者：Bulent Erdogan Fatma Elif UsturalıKeskin ErkanÖzcan Ahmet Küçükarda Ali Kaan Güren Osman Köstek Bekir Muhammet Hacioglu Hilmi Kodaz 

机构地区：[1]Department of Medical Oncology,Division of Medical Oncology,Department of Internal Medicine,Trakya University School of Medicine,Edirne 22000,Türkiye [2]Department of Pathology,Trakya University School of Medicine,Trakya University,Edirne 22000,Türkiye [3]Division of Medical Oncology,Trakya University School of Medicine,Edirne 22000,Türkiye [4]Division of Medical Oncology,Department of Internal Medicine,Trakya University School of Medicine,Edirne 22000,Türkiye [5]Division of Medical Oncology,Department of Internal Medicine,Marmara University School of Medicine,Marmara University,Istanbul 34000,Türkiye [6]Division of Medical Oncology,Department of Internal Medicine,Marmara University School of Medicine,Istanbul 34000,Türkiye [7]Department of Medical Oncology,Acibadem Eskisehir Hospital,Eskisehir 26130,Türkiye

出　　处：《World Journal of Gastrointestinal Oncology》2025年第3期113-121,共9页世界胃肠肿瘤学杂志(英文)

摘　　要：BACKGROUND The decision to administer adjuvant chemotherapy to patients with local stage depends on specific high-risk features that are T4 tumor stage,presence of perineural invasion,lymphovascular invasion,poorly differentiated tumor histology,inadequate lymph node sampling(fewer than 12 lymph nodes),and evidence of tumor perforation or obstruction.Tumor-stroma ratio,tumor infiltrating lymphocytes(TIL),Crohn-like reaction(CLR),desmoid reaction,poorly differentiated clusters(PDC)are new pathological markers that are being studied.AIM To examine the relationship between new pathological markers and defined high METHODS We evaluated 155 patients with the diagnosis stage I and II colorectal cancer between the years 2007 and 2021 who were treated at Trakya University Hospital,Department of Medical Oncology.We divided those with and without high-risk factors into two groups.We examined the relationship of new pathological markers with these groups and with pathological markers in risk factors.RESULTS There was no statistically significant correlation between presence of TIL,presence of PDC,presence of tumor budding,presence of CLR,presence of desmoid reaction and low and high-risk groups according to the degree of those with PDC(P=0.82,P=0.51,P=0.77,P=0.37,P=0.83,respectively).In addition,no statistically significant correlation was found between the tumor-stroma ratio and low and high risk groups(P=0.80).We found a statistically significant correlation between the presence of PDC and the presence of PDC grade 3 and T stage(P=0.001,P=0.001,respectively).It was determined that the presence of PDC and the frequency of grade 3 PDC increased with the advanced T stage.CONCLUSION No relationship was found between the presence of new pathological markers and high-low risk groups.When we examined the relationship between new and old pathological markers,only the frequency of detection of PDC and PDC grade 3 was found to be correlated with advanced T stage.

关 键 词：Colon cancer Early stage Risk factors New pathological markers Tumor-stroma ratio Tumor infiltrating lymphocytes Crohn-like reaction Desmoid reaction Poorly differentiated clusters 

分 类 号：R73[医药卫生—肿瘤]