Penile metastasis from colon cancer with BRAF_(V600E)mutation treated with BRAF/MEK-targeted therapy plus cetuximab:A case report  

作　　者：Jun-Chen Wu Hua-Xi Cheng Qiu-Sheng Lan He-Yang Xu Yu-Jie Zeng Wei Lai Zhong-Hua Chu 

机构地区：[1]Department of Gastrointestinal Surgery,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,Guangdong Province,China

出　　处：《World Journal of Gastrointestinal Oncology》2025年第3期402-409,共8页世界胃肠肿瘤学杂志(英文)

基　　金：National Natural Science Foundation of China,No.81871981;Natural Science Foundation of Guangdong Province,No.2022A1515012348 and No.2023A1515010457.

摘　　要：BACKGROUND The incidence of colon cancer has been progressively increasing over time,whereas penile metastasis of colon cancer has remained exceedingly uncommon.Since the prognosis for colon cancer with BRAF_(V600E)mutation is relatively unfavorable,further exploration and investigation are still required to develop treatment strategies for such rare cases.CASE SUMMARY About one year after surgery and chemotherapy,a 50-year-old patient with sigmoid colon cancer developed a mass at the base of the patient's penis,accompanied by severe tenderness and pain during urination.With disease progression,multiple metastatic nodules also emerged in other regions of the penis,including the coronal sulcus.The nodules located in the coronal sulcus were excised for histopathological examination.The histopathological findings revealed that the nodules were metastases originating from the sigmoid colon cancer,with a BRAF V600E mutation detected.This prompted a modification of the therapy regimen of cetuximab,dabrafenib and trametinib,which effectively held back the progression of penile metastasis in the patient.CONCLUSION Combining the BRAF/MEK-targeted therapy with cetuximab demonstrates a favorable therapeutic response in BRAF_(V600E)-mutated colon cancer with penile metastasis.

关 键 词：Colon cancer Penile metastasis BRAF_(V600E)mutation Targeted therapy Case report 

分 类 号：R73[医药卫生—肿瘤]