Advances in imaging techniques for tumor microenvironment evaluation in hepatocellular carcinoma  

作　　者：Li-Li Wang Fa-Chang Zhang Han-Xin Xu Dian-Dian Deng Bing-Jie Ren Qi Tan Ya-Xin Liu Wen-Hui Zhao Jia-Le Lu 

机构地区：[1]Department of Radiology,The First Hospital of Lanzhou University,Lanzhou 730030,Gansu Province,China [2]First Clinical Medical School of Lanzhou University,Lanzhou University,Lanzhou 730030,Gansu Province,China

出　　处：《World Journal of Gastroenterology》2025年第10期30-37,共8页世界胃肠病学杂志(英文)

基　　金：Supported by the National Natural Science Foundation of China,No.82360132;the First Hospital of Lanzhou University,No.ldyyyn2020-14.

摘　　要：The tumor microenvironment(TME)plays a critical role in the development and treatment of liver cancer,which ranks sixth in incidence and third in mortality worldwide,according to the“Global Cancer Statistics 2022”.Hepatocellular carcinoma(HCC),the most common form of liver cancer,is heavily influenced by the TME,which affects tumor growth,invasion,metastasis,and the response to various treatments.Despite advancements in surgery,liver transplantation,targeted therapies,and immunotherapy,the complexity of the TME often limits treatment efficacy,especially in advanced-stage HCC cases.The TME consists of a dynamic interaction between tumor cells,immune cells,fibroblasts,blood vessels,and signaling molecules,all of which contribute to cancer progression and therapy resistance.Assessing the HCC TME is essential for designing effective,personalized treatments and improving patient outcomes.Recent research highlights the value of imaging technologies as non-invasive tools to evaluate the TME,offering new possibilities for more targeted therapies and better prognosis monitoring in HCC patients.

关 键 词：Hepatocellular carcinoma Tumor microenvironment Imaging diagnosis Non-invasive assessment Molecular imaging 

分 类 号：R735.7[医药卫生—肿瘤]