从肠道菌群角度认识阿尔茨海默病的潜在发病机制  

UNDERSTANDING THE POTENTIAL PATHOGENIC MECHANISMS OF ALZHEIMER'S DISEASE FROM THE PERSPECTIVE OF GUT MICROBIOTA

作　　者：刘中华 张欣[2] LIU Zhonghua;ZHANG Xin(Dpartment on General Pactice,The Aflireda Hopial od Iner Mogolia Medical Univesit Hohor 0050 Chine;Department of Pysiology,lner Mongolia Medical Univrsit,Hobhot 010059 China)

机构地区：[1]内蒙古医科大学附属医院全科医学科,内蒙古呼和浩特010050 [2]内蒙古医科大学生理学教研室,内蒙古呼和浩特010059

出　　处：《内蒙古医科大学学报》2024年第6期640-644,共5页Journal of Inner Mongolia Medical University

基　　金：内蒙古自然基金项目(2020MS08139);内蒙古卫生健康委医疗卫生科技计划项目(202201195);内蒙古医科大学联合项目(YKD2023LH043)。

摘　　要：肠道菌群与阿尔茨海默症(alzheimer’s disease,AD)之间存在密切关联。AD是一种逐渐恶化的神经退行性疾病,其具体发病机制尚不明确。近年来,随着菌群-肠-脑轴研究的兴起,人们对肠道菌群在AD的发生和发展中所扮演的角色日益重视。肠道菌群的调节有望成为治疗AD的新途径。它通过影响肠道功能,通过微生物-肠-脑轴调节神经元的发育,而肠道菌群紊乱则导致神经系统疾病。肠道菌群失调引起的中枢神经功能紊乱、慢性炎症、β-样淀粉蛋白(Aβ)沉积、递质失衡和氧化应激等都会加重AD的进展。这些研究为我们提供了一种新的视角,以理解阿尔茨海默病的发病机制,并为开发新的治疗方法提供了可能性。There is a close association between gut microbiota and alzheimer's disease(AD).AD is a gradually deteri-o-rating neurodegenerative disease,and its specific pathogenesis is not yet clear.In recent years,with the rise of research on the microbiota gut brain axis,people have increasingly paid attention to the role of gut microbiota in the occurrence and develop-ment of AD.The regulation of gut microbiota is expected to become a new approach for treating AD.It regulates the development of neurons through the microbiota gut brain axis by affecting intestinal function,while disruption of gut microbiota leads to neu-rological disorders.Central nervous system dysfunction,chronic inflammation caused by dysbiosis of gut microbiotaβ-Amyloid protein(Aβ)Sedimentation,neurotransmitter imbalance,and oxidative stress can all exacerbate the progression of AD.These studies provide us with a new perspective to understand the pathogenesis of Alzheimer's disease and offer possibilities for devel-oping new treatment methods.

关 键 词：阿尔茨海默病 肠道菌群 微生物-肠-脑轴 益生菌 

分 类 号：R363.4[医药卫生—病理学]