肺癌中乏氧环境对循环肿瘤细胞侵袭转移的研究进展  

RESEARCH PROGRESS OF HYPOXIC ENVIRONMENT ON INVASION AND METASTASIS OF CIRCULATING TUMOR CELLS IN LUNG CANCER

作　　者：薛艳芳 王立红[2] XUE Yanfang;WANG Lihong(Inner Mongolia Medical University,Hohhot 010059,China;Department of Pulmonary and Critical Care Medicine,The Afiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学,内蒙古呼和浩特010059 [2]内蒙古医科大学附属医院呼吸与危重症学科,内蒙古呼和浩特010050

出　　处：《内蒙古医科大学学报》2024年第6期664-668,672,共6页Journal of Inner Mongolia Medical University

基　　金：内蒙古医科大学面上项目(YKD2021MS017)。

摘　　要：转移是肿瘤发生中最致命的事件。近年来,循环肿瘤细胞(circulating tumor cells,CTC)作为肿瘤转移的关键因素,在癌症患者的早期诊断、疗效评估以及预后评价等多方面显示出重要的价值,受到了广泛关注。临床上,乏氧环境与多种类型肿瘤的远处转移增加和生存率降低相关。因此,本文就乏氧环境对肺癌中CTC产生、进入循环系统及远处定植等方面的最新研究进展进行综述。Metastasis is the deadliest event in tumorigenesis.In recent years,circulating tumor cells,as a key factor of tumor metastasis,have shown important value in early diagnosis,curative effect evaluation and prognosis evaluation of cancer patients.Clinically,hypoxic environment is associated with increased distant metastasis and decreased survival rate of many types of tumors.Therefore,this paper reviews the latest research progress of hypoxic environment on the production,entry into circulatory system and distant colonization of circulating tumor cells in lung cancer.

关 键 词：CTC 乏氧 肿瘤微环境 上皮—间充质转化 

分 类 号：R734.2[医药卫生—肿瘤]