Contributions from light level and spectral content on refractive development in young rabbits  

作　　者：Xiu-Ping Tang Zhi-Jin Tang Hao-Bo Fan Yun-Chun Zou 

机构地区：[1]Department of Ophthalmology,the Second Clinical College of North Sichuan Medical College(Nanchong Central Hospital),Nanchong 637000,Sichuan Province,China [2]Department of Ophthalmology,Suining Central Hospital,Suining 629000,Sichuan Province,China [3]Department of Optometry,North Sichuan Medical College,Nanchong 637000,Sichuan Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2025年第3期390-397,共8页国际眼科杂志(英文版)

基　　金：Supported by Natural Science Foundation of Sichuan Province(No.2022NSFSC0754);Project of Nanchong Science and Technology Bureau(No.22SXQT0350).

摘　　要：AIM:To compare the effects of manipulating light levels versus manipulating the spectral content of short wavelengths(blue light)of ambient lighting on refractive development in young rabbits.METHODS:A total of 32 healthy 3-week-old rabbits were randomly assigned to one of the four groups with 8 in each group for 12wk:Control group(NC)under low blue light(output ratio of blue light 1.8%)at low illuminance(341 lx),HI group under low blue light(output ratio of blue light 1.6%)at high illuminance(5057 lx),simulating natural light(S-NL)group under high blue light(output ratio of blue light 4.9%)at high illuminance(5052 lx),and MB group under high blue light(output ratio of blue light 5.2%)at low illuminance(342 lx).The lighting in each group were provided by light emitting diode(LED)lamps emitting visible light(range 380-780 nm)in addition to(or not)LED lamps only emitting short wavelength(range 380-500 nm).Refraction,axial length,and corneal curvature radius were assessed by retinoscopy,ultrasonography and keratometry,respectively.Average data of both eyes for each animal were used as single values and compared among groups.RESULTS:During the 12-week intervention,all animals had an emmetropization period.The decrease of refraction in rabbits in HI group was similar to S-NL group,both slower than that of NC group(P<0.001).At the 12th week,the refraction(3.000±0.267 D)and vitreous cavity depth(7.421±0.168 mm)of S-NL was similar to HI group(3.250±0.267 D,7.264±0.256 mm),significantly different from NC group(1.937±0.291 D,7.825±0.313 mm;P<0.001 for both).High blue light at low illuminance had little effect on refraction change.At the end of intervention,the difference of refraction(2.219±0.281 D)and vitreous cavity depth(7.785±0.229 mm)in MB group were not statistically significant(P=0.311,P=0.749)compared with NC group.The other components were less affected by lighting conditions(P>0.05).CONCLUSION:The light levels per se but not the rich in spectral content of short wavelengths determine the inhibitory effect

关 键 词：EMMETROPIZATION MYOPIA refractive error ILLUMINANCE short wavelengths 

分 类 号：TN2[电子电信—物理电子学]