Different administration regimens of compound tropicamide eyedrops for pupil dilation for children with dark iris:a randomized clinical trial  

作　　者：Xu Xu Lian-Xin Zhang Jing-Jing Jiang 

机构地区：[1]National Center for Children’s Health,MOE Key Laboratory of Major Diseases in Children,Department of Ophthalmology,Beijing Children’s Hospital,Capital Medical University,Beijing 100045,China

出　　处：《International Journal of Ophthalmology(English edition)》2025年第3期415-419,共5页国际眼科杂志(英文版)

基　　金：Supported by the National Natural Science Foundation of China(No.82371093,No.72342015);R&D Program of Beijing Municipal Education Commission(No.KZ202110025039).

摘　　要：AIM:To compare the efficacy of different administration regimens of compound tropicamide eyedrops(CTE)for pupil dilation for children with dark iris.METHODS:A prospective,comparative,randomized interventional study was conducted.Children in Group 1 received CTE 3 times with a 3min interval between each application.Children in Group 2 received CTE 4 times with a 5min interval between each application.We measured their pupil diameters at baseline(pre-drug instillation)and 30min and 60min post-drug instillation and assessed the pupillary light reflex at 60min post-drug instillation.RESULTS:In total,194 eyes of 101 children were enrolled.The changes of pupil diameter at 30min and 60min post-drug instillation were 1.2±0.6 mm and 2.3±1.0 mm in Group 1,and 2.3±0.9 mm and 3.7±1.0 mm in Group 2,respectively.Group 2 showed a larger change in pupil size than Group 1 at 30min(P<0.01)and 60min(P<0.01).The effect of pupil dilation in Group 2 was 1.25 times that in Group 1.The change in pupil size was positively associated with age.A higher proportion of children in Group 1 had smaller pupil diameter and reactive pupils at the final time point,with only 33 children(33.7%)had final pupil size≥6.5 mm,and only 9 children(9.2%)had non-reactive pupils.Children in Group 2 achieved larger pupil diameter and more nonreactive pupils at the final time point,with 84 children(87.5%)had final pupil size≥6.5 mm,and only 22 children(22.9%)had reactive pupils.CONCLUSION:Increasing the frequency of compound tropicamide and lengthening the interval between eye drop applications can produce stronger mydriatic effects.

关 键 词：pupil dilation MYDRIASIS compound tropicamide dark iris CHILDREN 

分 类 号：R779.6[医药卫生—眼科]