Dynamic changes of spontaneous brain activity in patients after LASIK:a resting-state fMRI study  

作　　者：Hui Zhang Zi-Song Xu Jin-Yu Hu Zhen-Zhe Liu Lei Zhong Liang-Qi He Cheng Chen Xiao-Yu Wang Hong Wei Yan-Mei Zeng Qian Ling Xu Chen Yi-Xin Wang Yi Shao 

机构地区：[1]Nanchang Bright Eye Hospital,Nanchang 330000,Jiangxi Province,China [2]Department of Ophthalmology,the First Affiliated Hospital,Jiangxi Medical College,Nanchang University,Nanchang 330006,Jiangxi Province,China [3]Department of Ophthalmology,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine/National Clinical Research Center for Eye Diseases,Shanghai Key Laboratory of Ocular Fundus Diseases,Shanghai Engineering Center for Visual Science and Photomedicine,Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases,Shanghai 200080,China [4]Ophthalmology Centre of Maastricht University,Maastricht 6200MS,Limburg Provincie,the Netherlands [5]School of Optometry and Vision Science,Cardiff University,Cardiff,CF244HQ,Wales,UK

出　　处：《International Journal of Ophthalmology(English edition)》2025年第3期487-495,共9页国际眼科杂志(英文版)

基　　金：Supported by National Natural Science Foundation of China(No.82160195;No.82460203);Key R&D Program of Jiangxi Province(No.20223BBH80014).

摘　　要：AIM:To investigate changes in local brain activity after laser assisted in situ keratomileusis(LASIK)in myopia patients,and further explore whether post-LASIK(POL)patients and healthy controls(HCs)can be distinguished by differences in dynamic amplitude of low-frequency fluctuations(dALFF)in specific brain regions.METHODS:The resting-state functional magnetic resonance imaging(rs-fMRI)data were collected from 15 myopic patients who underwent LASIK and 15 matched healthy controls.This method was selected to calculate the corresponding dALFF values of each participant,to compare dALFF between the groups and to determine whether dALFF distinguishes reliably between myopic patients after LASIK and HCs using the linear support vector machine(SVM)permutation test(5000 repetitions).RESULTS:dALFF was lower in POL than in HCs at the right precentral gyrus and right insula.Classification accuracy of the SVM was 89.1%(P<0.001).CONCLUSION:The activity of spontaneous neurons in the right precentral gyrus and right insula of myopic patients change significantly after LASIK.SVM can correctly classify POL patients and HCs based on dALFF differences.

关 键 词：laser assisted in situ keratomileusis resting-state functional magnetic resonance imaging dynamic brain activity amplitude of low-frequency fluctuations support vector machine 

分 类 号：R73[医药卫生—肿瘤]