Potential immune involvement in cataract:from mechanisms to future scope of therapies  

作　　者：Lu Chen Ke Yao Qiu-Li Fu 

机构地区：[1]Eye Center,the Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310009,Zhejiang Province,China [2]Zhejiang Provincial Key Laboratory of Ophthalmology,Zhejiang Provincial Clinical Research Center for Eye Diseases,Zhejiang Provincial Engineering Institute on Eye Diseases,Hangzhou 310009,Zhejiang Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2025年第3期541-548,共8页国际眼科杂志(英文版)

基　　金：Supported by the National Natural Science Foundation of China(No.82271063;No.82471054);Central Guidance for Local Scientific and Technological Development Funding Projects(No.2024ZY01057).

摘　　要：The immune system is involved in many age-related pathological changes,also plays an important role in tissue regeneration after injury.But no immune involvement has been discussed regarding cataract since it is presumed that lens has no source of immune cells as an avascular zone.Latest research has challenged the longstanding view of the lens as an immune-privileged tissue,revealing the presence of resident immune cells and active immune responses within the lens.Thus,we summarized the immune involvement in maintaining lens homeostasis,which may be a deleterious role in the induction of lens opacification if inappropriately activated.Furthermore,bioengineer-based immunomodulatory therapies to fine-tune the micro immune environment within lens may be future strategies for in situ lens regeneration,as a novel treatment for cataract.

关 键 词：LENS CATARACT immune involvement lens regeneration 

分 类 号：R776.1[医药卫生—眼科]