血清SIRT1、SOX2水平与结肠癌术后1年肝转移的关系分析  

Relationship between serum SIRT1 and SOX2 levels and liver metastasis one year after colorectal cancer surgery

作　　者：黄彦泽 聂亚丽 Huang Yanze;Nie Yali(Department of Radiotherapy,Southern Theater General Hospital,Guangzhou 510000,China)

机构地区：[1]南部战区总医院放射治疗科,广东广州510000 [2]南部战区总医院放射全科医学科,广东广州510000

出　　处：《海军医学杂志》2025年第2期184-188,共5页Journal of Navy Medicine

基　　金：广东省医学科学技术研究基金项目(C2023116)。

摘　　要：目的探讨血清沉默信息调节因子1(SIRT1)、性别决定区Y框蛋白2(SOX2)水平与结肠癌术后1年肝转移的关系。方法选取2020年12月至2023年2月南部战区总医院112例结肠癌患者为研究对象,均进行腹腔镜结肠癌根治术,术前1 d均检测血清SIRT1、SOX2水平。术后随访1年,统计肝转移发生情况。将术后1年发生肝转移的患者纳入观察组,其余无肝转移的患者纳入对照组。分析SIRT1、SOX2与结肠癌术后肝转移的关系及两者对结肠癌术后肝转移的预测价值。结果112例结肠癌患者术后随访1年,失访6例,有效随访106例,出现肝转移33例(31.13%),纳入观察组,其余73例无肝转移的患者纳入对照组。观察组血清SIRT1水平低于对照组,血清SOX2水平高于对照组(P<0.05)。调整分化程度、浸润深度、淋巴结转移后,SIRT1每降低1%,SOX2每增加1%,结肠癌术后肝转移发生风险分别增加1.123倍、1.925倍(P<0.05),logit(P)=-1.938-0.754×SIRT1+1.073×SOX2。SIRT1、SOX2联合评估结肠癌术后肝转移的曲线下面积(AUC)大于SIRT1、SOX2单独评估(Z=2.107,P=0.035;Z=2.481,P=0.013)。结论血清SIRT1水平降低、SOX2水平升高会增加结肠癌术后肝转移风险,SIRT1、SOX2可作为预测结肠癌患者术后肝转移的潜在指标。Objective To investigate the relationship between serum levels of silent information regulator 1(SIRT1)and(sex determining region Y-box protein 2(SOX2))and liver metastasis one year after colorectal cancer surgery.Methods A total of 112 patients who underwent laparoscopic radical operation for colorectal cancer in Southern Theater General Hospital from December 2020 to February 2023 were selected as research objects.Serum SIRT1 and SOX2 levels were detected one day before surgery.Liver metastasis was recorded during one-year follow-up.The patients with liver metastasis were included in the observation group,while patients without liver metastasis were assigned to the control group.The relationship between serum levels of SIRT1 and SOX2 and liver metastasis after colon cancer surgery and the evalution value of both for liver metastasis after surgery in colon cancer patients were analyzed.Results Six patients failed to be followed up,33 patients(31.13%)suffered from liver metastasis one year after surgery(observation group),and the other 73 patients without liver metastasis were included in control group.The observation group had lower SIRT1 and higher SOX2 than the control group(P<0.05).After adjustment of differentiated degree,depth of invasion,and lymph node metastasis,the risk of postoperative liver metastasis in colon cancer patients increased by 1.123 and 1.925 times,respectively(P<0.05),when SIRT1 decreased by 1%and SOX2 increased by 1%,with logit(P)=-1.938-0.754×SIRT1+1.073×SOX2.The area under curve of SIRT1 combined with SOX2 for the evaluation of postoperative liver metastasis in colon cancer patients was greater than SIRT1 and SOX2 alone(Z=2.107,P=0.035;Z=2.481,P=0.013).Conclusion Decreased SIRT1 and increased SOX2 may increase the risk of postoperative liver metastasis in patients with colon cancer.SIRT1 and SOX2 have the potential to serve as predictive indicators for liver metastasis after surgery in colon cancer patients.

关 键 词：沉默信息调节因子1 性别决定区Y框蛋白2 结肠癌 术后肝转移 

分 类 号：R574.62[医药卫生—消化系统]