北京地区990名健康儿童血清维生素D水平分析  

Serum vitamin D levels of 990 healthy children in Beijing

作　　者：马少杰 毕颖薇 韩颖 王红 Ma Shaojie;Bi Yingwei;Han Ying;Wang Hong(Department of Pediatrics,Civil Aviation General Hospital,Beijing 100123,China)

机构地区：[1]民航总医院儿科,北京100123

出　　处：《海军医学杂志》2025年第2期194-199,共6页Journal of Navy Medicine

基　　金：首都卫生发展青年基金(首发2014-4-6031)。

摘　　要：目的了解北京地区健康儿童血清维生素D水平,探讨影响维生素D水平的相关因素。方法随机选取2016年9月至2020年9月于民航总医院儿科体检的1~14岁健康儿童,收集其临床资料、填写调查问卷,应用液相色谱-串联质谱(LC-MS/MS)法测定血清25-羟维生素D[25-(OH)D]水平,比较不同组别(根据年龄、性别、季节、户外活动时间、维生素D制剂补充情况分组)间25-(OH)D水平差异,并对结果进行统计分析。结果符合纳入标准的儿童共990名,年龄(6.42±3.50)岁;男500例,女490例。入选儿童血清25-(OH)D水平为11.70~51.90 ng/ml[(28.23±6.74)ng/ml];不同年龄组血清25-(OH)D水平:幼儿组(31.99±6.47)ng/ml,学龄前组(27.54±6.49)ng/ml,学龄组(25.84±5.93)ng/ml;幼儿组与学龄前、学龄组比较差异有统计学意义(P<0.05),学龄前和学龄组比较差异无统计学意义(P>0.05);不同年龄分组儿童血清25-(OH)D水平分类占比经Fisher精确检验统计分析差异有统计学意义(P<0.05),3组25-(OH)D正常、25-(OH)D不足、25-(OH)D缺乏占比差异均有统计学意义(P<0.05)。男、女童血清25-(OH)D总体水平和同年龄组水平比较差异无统计学意义(P>0.05),同性别不同年龄儿童组间25-(OH)D水平比较差异均有统计学意义(P<0.05);男、女童血清25-(OH)正常、25-(OH)D不足、25-(OH)D缺乏占比比较差异均无统计学意义(P>0.05)。夏季儿童血清25-(OH)D水平及血清25-(OH)D正常占比均最高,冬季最低,不同季节儿童血清25-(OH)D水平及25-(OH)D正常占比比较差异均有统计学意义(P<0.05)。户外活动≥1 h/d儿童的血清25-(OH)D水平高于户外活动时间<1 h/d的儿童,差异有统计学意义(P<0.05);2组在血清25-(OH)D正常、25-(OH)D不足、25-(OH)D缺乏占比比较差异均有统计学意义(P<0.05)。从不补充组和有时补充组儿童25-(OH)D水平均低于每天补充组,3组比较差异有统计学意义(P<0.05);3组在血清25-(OH)D正常、25-(OH)D不足、25-(OH)D缺乏占比比�Objective To investigate serum vitamin D levels of healthy children in Beijing and to analyze the factors affecting vitamin D level.Methods Healthy children aged 1-14 years old who underwent physical examination in department of pediatrica,Civil Aviation General Hospital from September 2016 to September 2020 were randomly selected as research objects.Clinical data of the children were collected and a questionnaires survey was conducted.The level of 25-hydroxy vitamin D[25-(OH)D]was detected by liquid chromatography-tandem mass spectrometry.Serum 25-(OH)D levels were compared between different groups(grouped by age,gender,season,outdoor activity time,and vitamin D supplementation).Results A total of 990 children met the inclusion criteria.There were 500 boys and 490 girls,with a mean age of(6.42±3.50)years old.The mean serum level of 25-(OH)D was(28.23±6.74)ng/ml in all the selected children(range,11.70-51.90 ng/ml),(31.99±6.47)ng/ml in young child group,(27.54±6.49)ng/ml in preschool group,and(25.84±5.93)ng/ml in school-age group.The serum level of 25-(OH)D in the young child group was significantly higher than those in the preschool group and school-age group(P<0.05).There was no significant difference in the serum level of 25-(OH)D between the preschool group and school-age group(P>0.05).There were significant differences in the proportions of children with normal 25-(OH)D,insufficient 25-(OH)D and deficient 25-(OH)D among different age groups(P<0.05).There was no significant difference in the serum level of 25-(OH)D between boys and girls in the same age group(P>0.05).There was significant difference in 25-(OH)D levels among different age groups with a same gender(P<0.05).There was no significant difference in the proportions of children with normal 25-(OH)D,insufficient 25-(OH)D,or deficient 25-(OH)D between boys and girls(P>0.05).The level of serum 25(-OH)D and the proportion of children with normal serum 25(-OH)D reached the highest in summer and the lowest in winter.There were significant differences

关 键 词：液相色谱-串联质谱(液相质谱) 25-羟维生素D 健康儿童 

分 类 号：R151.42[医药卫生—营养与食品卫生学]