双相情感障碍与乳腺癌的因果关系:两样本孟德尔随机化研究  

The relationship between bipolar disorder and breast cancer:a two-sample Mendelian randomization study

作　　者：马婷婷 赵晓莉 郭小龙 范春玲[2] 张银芳 曹娟 宋鹏 樊景春 MA Tingting;ZHAO Xiaoli;GUO Xiaolong;FAN Chunling;ZHANG Yinfang;CAO Juan;SONG Peng;FAN Jingchun(School of Public Health,Gansu University of Chinese Medicine,Lanzhou 730000,China;Department of Pharmacy,Gansu Provincial Cancer Hospital,Lanzhou 730050,China;Department of Laboratory Medicine,Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730000,China;Infection Management Office,Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730000,China;Experimental and Achievement Transformation Center,Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730000,China;Evidence-Based Medicine Center,Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学公共卫生学院,兰州730000 [2]甘肃省肿瘤医院药学部,兰州730050 [3]甘肃中医药大学附属医院检验科,兰州730000 [4]甘肃中医药大学附属医院院内感染管理办公室,兰州730000 [5]甘肃中医药大学附属医院实验与成果转化中心,兰州730000 [6]甘肃中医药大学循证医学中心,兰州730000

出　　处：《医学新知》2025年第2期161-167,共7页New Medicine

基　　金：国家自然科学基金地区科学基金项目(82260859);甘肃省教育厅高校教师-创新基金项目(2024A-084);吴阶平医学基金(320.6750.2022-20-21);甘肃省卫生健康行业科研计划项目(GSWSKY2022-81)。

摘　　要：目的探究双相情感障碍与乳腺癌及其亚型(雌激素受体阳性和阴性乳腺癌)之间的因果关系。方法使用双相情感障碍和乳腺癌的全基因组关联数据,对数据进行两样本孟德尔随机化分析,确定与双相情感障碍相关的单核苷酸多态性,并探究其与乳腺癌的关联。逆方差加权法(inverse-variance weighting,IVW)作为主要研究方法,MR Egger、加权中位数及加权众数作为补充,敏感性分析评估异质性和多效性。结果IVW分析显示,双相情感障碍与整体乳腺癌没有因果关系[OR=1.04,95%CI(0.98,1.12)],与两种亚型也没有因果关系(P>0.05);补充方法与IVW结果一致。敏感性分析显示结果可靠。结论双相情感障碍与整体乳腺癌之间没有因果关系,也不支持与某一亚型乳腺癌有因果关系。Objective To explore the causal relationship between bipolar disorder and breast cancer and its subtypes(estrogen receptor-positive and estrogen receptor-negative breast cancer).Methods Using genome-wide association data of bipolar disorder and breast cancer,a two-sample Mendelian randomization analysis was performed to identify single nucleotide polymorphisms associated with bipolar disorder and explore their association with breast cancer.The inverse-variance weighting(IVW)method served as the primary research approach,while MR Egger,weighted median estimator,and weighted mode were employed as supplementary methods.Sensitivity analyses were performed to assess heterogeneity and pleiotropy.Results The IVW analysis revealed no causal relationship between bipolar disorder and overall breast cancer[OR=1.04,95%CI(0.98,1.12)],nor with its two subtypes(P>0.05).The supplementary methods were consistent with the IVW findings.Sensitivity analyses indicated that the results were reliable.Conclusion There is no causal relationship between bipolar disorder and the risk of developing overall breast cancer,nor is there support for a causal relationship with a specific subtype of breast cancer.

关 键 词：双相情感障碍 乳腺癌 孟德尔随机化 雌激素受体阳性乳腺癌 雌激素受体阴性乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤] R749.4[医药卫生—临床医学]