Strengths,weaknesses,opportunities,and threats analysis of combination therapy for inflammatory bowel disease  

作　　者：Jia-Wang Yan Mei Nie Hang Zhang Yan-Miao Liu Fu-Shan Tang 

机构地区：[1]Department of Clinical Pharmacy,Zunyi Medical University,Zunyi 563006,Guizhou Province,China [2]Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education,Zunyi Medical University,Zunyi 563006,Guizhou Province,China [3]Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy,Zunyi Medical University,Zunyi 563006,Guizhou Province,China [4]The First Clinical Institute,Zunyi Medical University,Zunyi 563006,Guizhou Province,China

出　　处：《World Journal of Gastroenterology》2025年第9期176-182,共7页世界胃肠病学杂志(英文)

摘　　要：Inflammatory bowel disease(IBD),encompassing Crohn’s disease and ulcerative colitis,manifests as a chronic,recurrent,and refractory intestinal inflammatory condition significantly impacting patients’quality of life.Despite ongoing research,its etiology and pathogenesis remain incompletely understood.Recent advancements in medical research highlight the critical role of drug combination therapies in managing IBD.This paper employs the strengths,weaknesses,opportunities,and threats framework to evaluate the four strategic elements(strengths,weaknesses,opportunities,and threats)pertaining to combination therapies for IBD.Among the strengths,the paper underscores the efficacy of multi-targeted strategies,the advancement of personalized medicine,and the mitigation of drug resistance.Nonetheless,the analysis identifies significant weaknesses,including the prohibitive cost of treatment,issues with patient compliance,and the necessity for comprehensive long-term safety data.The paper also delineates opportunities to augment therapeutic success through the incorporation of biomarkers,the application of artificial intelligence,and extensive international collaborative efforts.In contrast,the paper does not shy away from addressing the threats,which include the potential for therapeutic resistance and the logistical challenges inherent in global therapy deployment.These initiatives aim to refine future therapeutic practices,fostering safer,more effective,and personalized treatment paradigms for IBD patients.

关 键 词：Inflammatory bowel disease Ulcerative colitis Crohn’s disease Combination therapy Strengths weaknesses opportunities threats analysis 

分 类 号：R57[医药卫生—消化系统]