艾地苯醌联合多巴丝肼治疗帕金森病患者的效果  

Effects of Idebenone combined with Levodopa and Benserazide in treatment of patients with Parkinson’s disease

作　　者：王欣 WANG Xin(1^(st)Ward of Department of Neurology of Xihua County People’s Hospital,Zhoukou 466600 Henan,China)

机构地区：[1]西华县人民医院神经内科一病区,河南周口466600

出　　处：《中国民康医学》2025年第4期27-29,33,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察艾地苯醌联合多巴丝肼治疗帕金森病(PD)患者的效果。方法:选取2021年4月至2022年4月该院收治的86例PD患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各43例。对照组给予多巴丝肼治疗,观察组在对照组基础上联合艾地苯醌治疗。比较两组临床疗效,治疗前后临床症状[统一帕金森病评定量表运动检查部分(UPDRS-Ⅲ)、帕金森病非运动症状评价量表(NMSS)]评分、氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)、8-羟基脱氧鸟苷酸(8-OHdG)]水平、生物标志物[生长分化因子-15(GDF-15)、α-突触核蛋白(α-Syn)]水平,以及不良反应发生率。结果:观察组治疗总有效率为93.02%(40/43),高于对照组的76.74%(33/43),差异有统计学意义(P<0.05);治疗后,两组UPDRS-Ⅲ、NMSS等临床症状评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组SOD水平均高于治疗前,且观察组高于对照组,两组MDA、8-OHdG水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组GDF-15、α-Syn水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:艾地苯醌联合多巴丝肼治疗PD患者,可提高临床疗效,减轻临床症状和机体氧化应激反应,降低生物标志物水平,效果优于单纯多巴丝肼治疗。Objective:To observe effects of Idebenone combined with Levodopa and Benserazide in treatment of patients with Parkinson’s disease(PD).Methods:86 patients with PD admitted to this hospital from April 2021 to April 2022 were selected for the prospective study.They were divided into control group and observation group according to the random number table method,43 cases in each group.The control group was treated with Levodopa and Benserazide,while the observation group was treated with Idebenone on the basis of that of the control group.The clinical efficacy,the clinical symptoms[unified Parkinson’s disease rating scale motor examination part(UPDRS-III),Parkinson’s disease non-motor symptom evaluation scale(NMSS)]scores,the oxidative stress indexes[superoxide dismutase(SOD),malondialdehyde(MDA),8-hydroxydeoxyguanosine(8-OHdG)]levels,the biomarkers[growth differentiation factor-15(GDF-15),α-synuclein(α-Syn)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 93.02%(40/43),which was higher than 76.74%(33/43)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of UPDRS-III,NMSS and other clinical symptoms in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The SOD levels of the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;the levels of MDA and 8-OHdG in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;the differences were statistically significant(P<0.05).The levels of GDF-15 andα-Syn in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and t

关 键 词：帕金森病 艾地苯醌 多巴丝肼 氧化应激 生物标志物 不良反应 

分 类 号：R742.5[医药卫生—神经病学与精神病学]