黄芪建中汤加减联合马来酸曲美布汀与奥美拉唑治疗消化性溃疡脾胃湿热证患者的效果  

Effects of Huangqi Jianzhong decoction combined with Trimebutine maleate and Omeprazole in treatment of peptic ulcer patients with spleen-stomach dampness-heat syndrome

作　　者：周斌 ZHOU Bin(Department of Internal Medicine of Lixu Township Hospital,Fuzhou 331807 Jiangxi,China)

机构地区：[1]黎圩镇卫生院内科,江西抚州331807

出　　处：《中国民康医学》2025年第4期93-96,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察黄芪建中汤加减联合马来酸曲美布汀与奥美拉唑治疗消化性溃疡脾胃湿热证患者的效果。方法:选取2020—2023年该院收治的83例消化性溃疡患者进行前瞻性研究,按照随机数字表法将其分为观察组(n=42)和对照组(n=41)。对照组采用马来酸曲美布汀与奥美拉唑治疗,观察组在对照组基础上联合黄芪建中汤加减治疗。比较两组治疗前后胃黏膜屏障功能指标[表皮生长因子(EGF)、二胺氧化酶(DAO)]水平、炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平、中医证候积分(脘腹疼痛、口干、泛酸、四肢倦怠、纳少、纳呆、嗳气),以及不良反应发生率。结果:治疗后,两组EGF水平均高于治疗前,且观察组高于对照组,两组DAO水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组TNF-α、IL-6水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组脘腹疼痛、口干、泛酸、四肢倦怠、纳少、纳呆、嗳气等中医证候积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:黄芪建中汤加减联合马来酸曲美布汀与奥美拉唑治疗消化性溃疡脾胃湿热证患者可改善胃黏膜屏障功能指标水平,降低炎性因子水平和中医证候积分,效果优于马来酸曲美布汀联合奥美拉唑治疗。Objective:To observe effects of Huangqi Jianzhong decoction combined with Trimebutine maleate and Omeprazole in treatment of peptic ulcer patients with spleen-stomach dampness-heat syndrome.Methods:A prospective study was conducted on 83 patients with peptic ulcer admitted to the hospital from 2020 to 2023.According to the random number table method,they were divided into observation group(n=42)and control group(n=41).The control group was treated with Trimebutine maleate and Omeprazole,while the observation group was treated with Huangqi Jianzhong decoction on the basis of that of the control group.The levels of gastric mucosal barrier function indexes[epidermal growth factor(EGF),diamine oxidase(DAO)]and inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],the TCM syndrome scores(abdominal pain,dry mouth,sour regurgitation,limb lassitude,anorexia,anorexia,belching)before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:After the treatment,the levels of EGF in the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;the DAO levels of the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of TNF-αand IL-6 in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the TCM syndrome scores of epigastric pain,dry mouth,pantothenic acid,limb fatigue,hyponatremia,anorexia,and belching in both groups were lower than before treatment,and the observation group was lower than the control group,with statistical significance(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions

关 键 词：消化性溃疡 脾胃湿热证 黄芪建中汤加减 马来酸曲美布汀 奥美拉唑 胃黏膜屏障功能 中医证候积分 

分 类 号：R573.1[医药卫生—消化系统]