血清肿瘤标志物、IL-6、IL-1β水平联合检测在肺癌诊断中的效能  

Efficiency of combined detection of serum tumor markers,IL-6 and IL-1βlevels in diagnosis of lung cancer

作　　者：王娟 桑原锋 杨瑞 代春雨 WANG Juan;SANG Yuanfeng;YANG Rui;DAI Chunyu(Department of Clinical Laboratory of West District Hospital of Nanyang First People’s Hospital,Nanyang 473000 Henan,China)

机构地区：[1]南阳市第一人民医院西区医院检验科,河南南阳473000

出　　处：《中国民康医学》2025年第4期116-118,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察血清肿瘤标志物、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)水平联合检测在肺癌诊断中的效能。方法:选取2022年1月至2023年11月该院收治的100例肺癌患者为研究组,另选取同期该院100名健康体检者为对照组。检测两组血清肿瘤标志物[鳞状细胞癌抗原(SCC-Ag)、细胞角质蛋白19片段抗原21-1(CYFRA21-1)、癌胚抗原(CEA)]和IL-6、IL-1β水平,比较两组血清肿瘤标志物、IL-6、IL-1β水平,并绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC),分析血清肿瘤标志物、IL-6、IL-1β水平单项及联合检测在肺癌诊断中的效能。结果:研究组血清SCC-Ag、CYFRA21-1、CEA、IL-6、IL-1β水平均高于对照组,差异有统计学意义(P<0.05);ROC曲线分析结果显示,血清SCC-Ag、CYFRA21-1、CEA、IL-6、IL-1β水平单项及联合检测诊断肺癌的AUC分别为0.680、0.774、0.769、0.784、0.756、0.937,其中联合检测的AUC最高。结论:血清肿瘤标志物、IL-6、IL-1β水平联合检测诊断肺癌的效能高于各指标单项检测。Objective:To observe efficiency of combined detection of serum tumor markers,interleukin-6(IL-6)and interleukin-1β(IL-1β)levels in diagnosis of lung cancer.Methods:A total of 100 patients with lung cancer admitted to this hospital from January 2022 to November 2023 were selected as the study group,and 100 healthy subjects during the same period were selected as the control group.The levels of serum tumor markers[squamous cell carcinoma antigen(SCC-Ag),cyto-keratin 19 fragment antigen 21-1(CYFRA21-1),carcinoembryonic antigen(CEA)],IL-6 and IL-1βwere detected in the two groups.The levels of serum tumor markers,IL-6 and IL-1βwere compared between the two groups.The receiver operating characteristic(ROC)curve was drawn,the area under the curve(AUC)was calculated,and the efficiency of single and combined detection of serum tumor markers,IL-6 and IL-1βlevels in the diagnosis of lung cancer were analyzed.Results:The levels of serum SCC-Ag,CYFRA21-1,CEA,IL-6 and IL-1βin the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).ROC curve analysis showed that the AUC of single and combined detection of serum SCC-Ag,CYFRA21-1,CEA,IL-6 and IL-1βlevels in the diagnosis of lung cancer were 0.680,0.774,0.769,0.784,0.756 and 0.937,separately,and the AUC of combined detection was the highest.Conclusions:The efficiency of combined detection of serum tumor markers,IL-6 and IL-1βlevels in the diagnosis of lung cancer is higher than that of single detection of each index.

关 键 词：肿瘤标志物 白细胞介素-6 白细胞介素-1Β 肺癌 诊断 

分 类 号：R734.2[医药卫生—肿瘤]