血清TNF-α、IL-6、PGE_(2)水平单项及联合检测预测非小细胞肺癌术后患者发生慢性疼痛的价值  

Value of single and combined detection of serum TNF-α,IL-6 and PGE_(2)levels in prediction of chronic pain in postoperative patients with non-small cell lung cancer

作　　者：王华昕 郭妍[1] 卫琼琼 WANG Huaxin;GUO Yan;WEI Qiongqiong(Department of Pulmonary Tumor Surgery of the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000 Henan,China)

机构地区：[1]河南科技大学第一附属医院肺肿瘤外科,河南洛阳471000

出　　处：《中国民康医学》2025年第4期119-121,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:分析血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、前列腺素E_(2)(PGE_(2))水平单项及联合检测预测非小细胞肺癌(NSCLC)患者术后发生慢性疼痛的价值。方法:选取2022年3月至2023年6月该院收治的85例行肺切除术的NSCLC患者进行前瞻性研究,根据术后3个月内是否发生慢性疼痛将其分为发生组40例与未发生组45例,另选取该院同期45名健康体检者作为对照组。比较三组血清TNF-α、IL-6、PGE_(2)水平,采用Spearman相关性分析血清TNF-α、IL-6、PGE_(2)水平与NSCLC术后患者慢性疼痛的相关性,绘制受试者工作特征(ROC)曲线分析血清TNF-α、IL-6、PGE_(2)水平单项及联合检测预测NSCLC术后患者发生慢性疼痛的价值。结果:发生组血清TNF-α、IL-6、PGE_(2)水平均高于未发生组、对照组,且未发生组高于对照组,差异有统计学意义(P>0.05);经Spearman相关性分析结果显示,血清TNF-α、IL-6、PGE_(2)水平与NSCLC术后患者慢性疼痛均呈正相关(r>0,P<0.05);经ROC曲线分析结果显示,血清IL-6、TNF-α、PGE_(2)水平单项及联合检测预测NSCLC术后患者发生慢性疼痛的曲线下面积分别为0.781、0.752、0.802、0.934,均具有一定预测价值,且联合检测的预测价值高于三者单项检测。结论:血清TNF-α、IL-6、PGE_(2)水平联合检测预测NSCLC术后患者发生慢性疼痛的价值高于三者单项检测。Objective:To analyze value of single and combined detection of serum tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and prostaglandin E_(2)(PGE_(2))levels in prediction of chronic pain in postoperative patients with non-small cell lung cancer(NSCLC).Methods:A prospective study was conducted on 85 postoperative patients with NSCLC who underwent pneumonectomy in this hospital from March 2022 to June 2023.According to whether chronic pain occurred within 3 months after the surgery,they were divided into 40 cases in the occurrence group and 45 cases in the non-occurrence group.In addition,45 healthy people who underwent physical examination during the same period were selected as the control group.The levels of serum TNF-α,IL-6 and PGE_(2)were compared among the three groups.Spearman correlation analysis was used to analyze the correlation among the serum TNF-α,IL-6,PGE_(2)levels and chronic pain in the postoperative patients with NSCLC.The receiver operating characteristic(ROC)curve was drawn to analyze the value of single and combined detection of serum TNF-α,IL-6 and PGE_(2)levels in the prediction of chronic pain in the postoperative patients with NSCLC.Results:The levels of serum TNF-α,IL-6 and PGE_(2)in the occurrence group were higher than those in the non-occurrence group and the control group,those in the non-occurrence group were higher than those in the control group,and the differences were statistically significant(P<0.05).Spearman correlation analysis showed that the serum TNF-α,IL-6 and PGE_(2)levels were positively correlated with chronic pain in the postoperative patients with NSCLC(r>0,P<0.05).ROC curve analysis showed that the area under the curve of single and combined detection of the serum IL-6,TNF-αand PGE_(2)levels in the prediction of chronic pain in the postoperative patients with NSCLC were 0.781,0.752,0.802 and 0.934,separately,which had certain predictive value,and the predictive value of the combined detection was higher than that of single detection.Conclusions:The value of c

关 键 词：非小细胞肺癌 慢性疼痛 肿瘤坏死因子-Α 白细胞介素-6 前列腺素E_(2) 

分 类 号：R734.2[医药卫生—肿瘤]