血清TGF-β1、Flt3 L、EGFR水平单项及联合检测对急性髓系白血病患者不良预后的预测价值  

Predictive value of single and combined detection of serum TGF-β1,Flt3 L and EGFR levels for poor prognosis in patients with acute myeloid leukemia

作　　者：陈星 李娟 CHEN Xing;LI Juan(Department of Clinical Laboratory of Hengyang Hospital of Traditional Chinese Medicine,Hengyang 421200 Hu’nan,China)

机构地区：[1]衡阳市中医医院检验科,湖南衡阳421200

出　　处：《中国民康医学》2025年第4期122-124,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:分析血清转化生长因子-β1(TGF-β1)、FMS样酪氨酸激酶3配体(Flt3L)、表皮生长因子受体(EGFR)水平单项及联合检测对急性髓系白血病(AML)患者不良预后的预测价值。方法:选取2020年8月至2023年8月该院收治的102例AML患者作为观察组,另选取同期50名健康体检者为对照组。比较两组及不同预后AML患者血清TGF-β1、Flt3L、EGFR水平,绘制受试者工作特征(ROC)曲线分析血清TGF-β1、Flt3L、EGFR水平单项及联合检测对AML患者不良预后的预测价值。结果:观察组血清TGF-β1、Flt3L水平均低于对照组,EGFR水平高于对照组,差异均有统计学意义(P<0.05);不良预后患者血清TGF-β1、Flt3L水平均低于预后良好患者,EGFR水平高于预后良好患者,差异有统计学意义(P<0.05);经ROC曲线分析结果显示,血清TGF-β1、Flt3L、EGFR水平单项及联合检测预测AML患者不良预后的曲线下面积分别为0.816、0.738、0.779、0.966,联合检测的预测价值高于三者单项检测。结论:血清TGF-β1、Flt3L、EGFR水平联合检测预测AML患者不良预后的价值高于三者单项检测。Objective:To analyze predictive value of single and combined detection of serum transforming growth factor-β1(TGF-β1),FMS-like tyrosine kinase 3 ligand(Flt3L)and epidermal growth factor receptor(EGFR)levels for poor prognosis in patients with acute myeloid leukemia(AML).Methods:A total of 102 patients with AML admitted to this hospital from August 2020 to August 2023 were selected as the observation group,and 50 healthy subjects were selected as the control group.The serum levels of TGF-β1,Flt3L and EGFR were compared between the two groups and between the AML patients with different prognosis.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of single and combined detection of the serum TGF-β1,Flt3L and EGFR levels in the poor prognosis of the AML patients.Results:The levels of serum TGF-β1 and Flt3L in the observation group were lower than those in the control group,the level of EGFR was higher than that in the control group,and the differences were statistically significant(P<0.05).The levels of serum TGF-β1 and Flt3L in the patients with poor prognosis were lower than those in the patients with good prognosis,the level of EGFR was higher than that in the patients with good prognosis,and the differences were statistically significant(P<0.05).The ROC curve analysis showed that the area under the curve of single and combined detection of the serum TGF-β1,Flt3L and EGFR levels in the prediction of poor prognosis of the AML patients were 0.816,0.738,0.779 and 0.966,separately,and the predictive value of combined detection was higher than that of single detection.Conclusions:The combined detection of serum TGF-β1,Flt3L and EGFR levels in the prediction of the poor prognosis of the AML patient is higher than the single detection of the three.

关 键 词：急性髓系白血病 不良预后 转化生长因子-Β1 FMS样酪氨酸激酶3配体 表皮生长因子受体 

分 类 号：R733.71[医药卫生—肿瘤]