孟德尔随机化在代谢相关(非酒精性)脂肪性肝病中的应用  

Application of Mendelian randomization in metabolic dysfunction-associated(nonalcoholic)fatty liver disease

作　　者：郑云飞 刘雪辉 张雪巍 李伟 邓鑫[1] Zheng Yunfei;Liu Xuehui;Zhang Xuewei;Li Wei;Deng Xin(College of Basic Medicine,Guangxi University of Chinese Medicine,Guangxi Nanning 530000,China;School of Graduate,Guangxi University of Traditional Chinese Medicine,Guangxi Nanning 530000,China)

机构地区：[1]广西中医药大学基础医学院,广西南宁530000 [2]广西中医药大学研究生院,广西南宁530000

出　　处：《中国肝脏病杂志(电子版)》2024年第4期31-37,共7页Chinese Journal of Liver Diseases:Electronic Version

基　　金：广西重大传染病互联网中医智慧诊疗平台建设(桂科ZY21195025);广西中医药大学“桂派中医药传承创新团队”(2022B004)。

摘　　要：代谢相关脂肪性肝病(metabolic associated fatty liver disease,MAFLD)曾称非酒精性脂肪性肝病(non-alcohol fatty liver disease,NAFLD),是一种常见的肝脏疾病,其发病率逐年上升,了解其危险因素对疾病的预防十分必要。传统观察性研究揭示了某些可控因素对NAFLD有一定影响,然而始终无法避免其固有的局限性,如混杂因素、测量误差及反向因果关系。孟德尔随机化研究是目前研究因果关系的一种新方法,主要应用单核苷酸多态性作为工具变量,代替可改变的暴露因素来研究危险因素与疾病间的因果关系。本文对已发表的关于NAFLD的孟德尔随机化研究进行总结,以期为探讨不同危险因素与NAFLD间的因果关系提供帮助。Metabolic associated fatty liver disease(MAFLD)was once called non-alcoholic fatty liver disease(NAFLD),which is a common liver disease.The incidence rate is increasing year by year.It is necessary to understand its risk factors for disease prevention.Traditional observational studies have revealed that certain controllable factors have an impact on NAFLD.However,it has never been able to avoid its inherent limitations such as confounding factors,measurement errors,and reverse causality.Mendelian randomization is a new method for studying causal relationships,mainly using single nucleotide polymorphisms as instrumental variables to replace modifiable exposure factors in studying the causal relationship between risk factors and diseases.This article summarized the published Mendelian randomization studies on NAFLD,in order to provide assistance in exploring the causal relationship between different risk factors and NAFLD.

关 键 词：代谢相关(非酒精性)脂肪性肝病 孟德尔随机化 因果关系 

分 类 号：R57[医药卫生—消化系统]