苯巴比妥联合卡马西平在惊厥性癫痫治疗中的应用效果  

The Application Effect of Phenobarbital Combined with Carbamazepine in the Treatment of Convulsive Epilepsy

作　　者：唐伯儒 孙珍珍 邹建 郝新斌 TANG Boru;SUN Zhenzhen;ZOU Jian;HAO Xinbin(Department of neurology,Liaoyang Central Hospital,Liaoyang,Liaoning 111000,China)

机构地区：[1]辽阳市中心医院神经内科,辽宁辽阳111000

出　　处：《中国医药指南》2025年第5期73-75,共3页Guide of China Medicine

摘　　要：目的分析苯巴比妥应用在惊厥性癫痫疾病患者治疗中的临床效果及对患者癫痫症状的改善效果。方法选取2023年3月至2024年3月辽阳市中心医院84例惊厥性癫痫患者,采用随机数字表法分为对照组和观察组,各42例。对照组单纯应用卡马西平治疗,观察组患者在此基础上加用苯巴比妥治疗。对两组患者癫痫发作次数、癫痫持续时间、临床症状好转时间加以对比,同时检测两组患者血清相关指标(GAL、NSE、GFAP、及BDNF水平),记录患者嗜睡、呼吸抑制、心率异常等不良反应发生情况,分析临床治疗效果。结果观察组患者总有效率97.62%比对照组85.71%更高(P<0.05);在癫痫发作次数少、癫痫持续时间短、临床症状好转时间方面,观察组(1.27±0.10)次/d、(1.36±0.12)min、(6.44±1.46)d好于对照组(1.27±0.10)次/d、(1.36±0.12)min、(6.44±1.46)d(P<0.05);观察组治疗后的血清甘丙肽、神经元特异性烯醇化酶、中枢神经特异性蛋白以及脑源性神经营养因子水平均比对照组低(P<0.05);两组不良反应发生率对比结果显示差异无统计学意义(P>0.05)。结论在惊厥性癫痫患者临床治疗过程中运用苯巴比妥会产生良好的治疗效果,可早期改善患者临床症状,对患者神经网络状态进行良性调节,保证治疗效果。Objective To analyze the clinical efficacy of phenobarbital in the treatment of patients with convulsive epilepsy and its improvement effect on epilepsy symptoms.Methods A total of 84 patients with convulsive epilepsy at Liaoyang Central Hospital from March 2023 to March 2024 were randomly divided into two groups of 42 each.The control group received carbamazepine alone,while the observation group received additional phenobarbital.The study compared seizure frequency,duration,and time to clinical improvement between the groups,measured serum levels of galanin,neuron-specific enolase,S-100βprotein,and brain-derived neurotrophic factor,and recorded adverse reactions such as somnolence,respiratory depression,and abnormal heart rate to evaluate treatment effectiveness.Results The observation group had a higher total effective rate of 97.62%compared to the control group’s 85.71%(P<0.05).The observation group also had fewer epileptic seizures(1.27±0.10)times per day,shorter seizure duration(1.36±0.12)minutes,and faster clinical symptom improvement(6.44±1.46)days than the control group(P<0.05).Post-treatment,the observation group had lower levels of serum galanin,neuron-specific enolase,central nervous system-specific protein,and brain-derived neurotrophic factor compared to the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions The use of phenobarbital in the clinical treatment of patients with convulsive epilepsy can produce good therapeutic effects,improve clinical symptoms in the early stage,regulate the neural network status of patients in a benign manner,and ensure treatment effectiveness.

关 键 词：惊厥性癫痫 苯巴比妥 卡马西平 治疗效果 不良反应 

分 类 号：R742.1[医药卫生—神经病学与精神病学]