运动通过调控BDNF/TrkB通路防治帕金森病研究进展  

Research Progress of Exercise in Prevention and Treatment of Parkinson's Disease by Regulating BDNF/TrkB Pathway

作　　者：周文辉 李刚强 ZHOU Wenhui;LI Gangqiang(Changde Vocational and Technical College,Changde 415000,China;School of Foreign Affairs,Central South University of Forestry and Science,Changsha 410000,China)

机构地区：[1]常德职业技术学院,常德415000 [2]中南林业科技大学涉外学院,长沙410000

出　　处：《中国细胞生物学学报》2025年第2期299-305,共7页Chinese Journal of Cell Biology

摘　　要：帕金森病(Parkinson’s disease,PD)是一种慢性进行性的神经系统疾病。脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)/酪氨酸激酶受体B(tyrosine kinase receptor B,TrkB)信号通路失调与PD发生发展有关。调控BDNF/TrkB信号通路已被认为是PD的一种治疗策略。运动疗法是一种无毒、低成本、普遍适用的非药理治疗手段,不仅可以降低PD的发病风险,而且在改善PD相关行为功能障碍方面均具有积极的作用,其机制可能是通过调控BDNF/TrkB信号通路来实现的。该文从BDNF/TrkB通路视角入手,对它在PD发生发展及PD运动防治中的可能作用等方面的研究进行综述。PD(Parkinson's disease)is a chronic progressive neurological disorder.Dysregulation of BDNF(brain-derived neurotrophic factor)/TrkB(tyrosine kinase receptor B)signaling pathway is associated with PD development.Regulation of the BDNF/TrkB signaling pathway has been suggested as a therapeutic strategy in PD.Exercise therapy is a non-toxic,low-cost and generally applicable non-pharmacological treatment that not only reduces the risk of PD,but also has a positive effect in improving PD-related behavioral dysfunction,and its mechanism may be achieved by regulating the BDNF/TrkB signaling pathway.This article reviews the possible role of BDNF/TrkB pathway in the occurrence and development of PD and the prevention and treatment of PD exercise.

关 键 词：运动 帕金森病 BDNF/TrkB通路 

分 类 号：R742.5[医药卫生—神经病学与精神病学]