Energy deprivation-induced autophagy and aggrephagy:insights from yeast and mammals  

作　　者：Siyu FAN Yingcong CHEN Weijing YAO Cong YI 

机构地区：[1]Department of Biochemistry,and Department of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第12期1066-1070,共5页浙江大学学报(英文版)B辑(生物医学与生物技术)

基　　金：supported by the Zhejiang Provincial Natural Science Foundation of China(No.LR21C070001);the National Natural Science Foundation of China(Nos.32122028,92254307,32070739,and 32100600)。

摘　　要：Autophagy plays a crucial role in maintaining cellular homeostasis in response to various stimuli.Compared to research on nutrient deprivation-induced autophagy,the understanding of the molecular mechanisms and physiological/pathological significance of autophagy triggered by energy deprivation remains limited.A primary focus of our lab is to elucidate how cells sense energy deprivation and initiate autophagy.Using the model organisms Saccharomyces cerevisiae and mammalian cells,we found that cellular reactive oxygen species(ROS),DNA damage sensor Mec1,and mitochondrial aerobic respiration play essential roles in the autophagy induced by energy deprivation.This review aims to provide a concise overview of these research findings.

关 键 词：AUTOPHAGY Glucose starvation Solid aggrephagy Chaperonin-containing TCP-1 subunit 2(CCT2) 

分 类 号：Q25[生物学—细胞生物学]