氯胺酮治疗抑郁症的机制研究进展  

Recent advances in the mechanism of ketamine for treating depression

作　　者：滕云[1] 王宾 TENG Yun;WANG Bin(Department of Radiotherapy,the Second Hospital of Dalian Medical University,Dalian 116027,China;Department of Physiology,Dalian Medical University,Dalian 116044,China)

机构地区：[1]大连医科大学附属第二医院放疗科,辽宁大连116027 [2]大连医科大学生理学教研室,辽宁大连116044

出　　处：《大连医科大学学报》2024年第6期481-487,共7页Journal of Dalian Medical University

基　　金：国家自然科学基金青年基金项目(82301700);辽宁省自然科学基金面上项目(2024-MS-157,2023-MS-266);大连医科大学青年人才培育基金重点项目;大连医科大学附属第二医院院内培育基金项目(XJ2023000501)。

摘　　要：现有的临床研究和动物实验已经证实氯胺酮有抗抑郁作用,其主要作用机制包括调节谷氨酸和γ氨基丁酸(GABA)系统、神经肽及其通路[脑源性神经营养因子(BDNF)、神经内分泌调节肽(VGF)]、下丘脑-垂体-肾上腺(HPA)轴和炎症因子及自噬活动等。然而,氯胺酮治疗抑郁症的确切机制尚不清楚,仍有待进一步阐明。本文综述了氯胺酮抗抑郁作用的最新临床证据和实验室研究进展,旨在为未来的临床应用提供参考。Existing clinical studies and animal experiments have confirmed the antidepressant effects of ketamine.The primary mechanisms of action include modulation of the glutamate and GABA systems,neuropeptides and their pathways(such as BDNF and VGF),the hypothalamic-pituitary-adrenal(HPA)axis,inflammatory factors,and autophagic activity.However,despite extensive research efforts,the precise antidepressant mechanism of ketamine remains elusive.This article provides a comprehensive review of recent clinical evidence and laboratory research advancements in the antidepressant effects of ketamine,aiming to offer insights and references for further investigation.

关 键 词：抑郁症 氯胺酮 谷氨酸 下丘脑-垂体-肾上腺轴 自噬 

分 类 号：R749.05[医药卫生—神经病学与精神病学]