腹部脂肪肉瘤免疫治疗的现状与前景:从基础研究到临床实践  

Current status and future perspectives of immunotherapy for abdominal liposarcoma:From basic research to clinical practice

作　　者：庄奥博 席哲 成映雪 张辰赫 李文岗[2,3] Ao-Bo Zhuang;Zhe Xi;Ying-Xue Cheng;Chen-He Zhang;Wen-Gang Li(School of Medicine,Xiamen University,Xiamen 361102,Fujian Province,China;Department of Hepatobiliary and Pancreatic Surgery,Xiang’an Hospital of Xiamen University,Xiamen 361102,Fujian Province,China;Cancer Research Center of Xiamen University,Xiamen 361005,Fujian Province,China)

机构地区：[1]厦门大学医学院,福建省厦门市361102 [2]厦门大学翔安医院肝胆胰血管外科,福建省厦门市361102 [3]厦门大学抗癌研究中心,福建省厦门市361005

出　　处：《世界华人消化杂志》2025年第2期81-88,共8页World Chinese Journal of Digestology

基　　金：福建省公益类竞争性项目,No.2023R1037.

摘　　要：脂肪肉瘤是一类源自脂肪组织的高度异质性的软组织肉瘤,具有复杂的生物学行为和侵袭性.传统治疗方法对高级别和转移性脂肪肉瘤的疗效有限,患者预后仍不理想.近年来,免疫治疗在多种实体瘤中取得了突破性进展,引起了对其在脂肪肉瘤中应用的浓厚兴趣.本文系统综述了脂肪肉瘤免疫治疗的基础研究进展和临床实践现状,深入探讨了肿瘤免疫微环境、免疫逃逸机制、免疫检查点抑制剂的应用、联合治疗策略,以及面临的挑战和未来发展方向.旨在为脂肪肉瘤的个体化治疗提供理论依据,促进新型免疫治疗策略的开发,最终改善患者的预后和生活质量.Liposarcoma is a highly heterogeneous type of soft tissue sarcoma originating from adipose tissue,characterized by complex biological behavior and invasiveness.Traditional treatments have shown limited efficacy in high-grade and metastatic liposarcoma,with unsatisfactory patient outcomes.In recent years,the breakthroughs of immunotherapy in various solid tumors have sparked interest in its potential application to liposarcoma.This review systematically examines the progress in basic research and clinical practice of immunotherapy for liposarcoma,discussing the tumor immune microenvironment,mechanisms of immune evasion,the application of immune checkpoint inhibitors,combination therapy strategies,the challenges faced,as well as the future direction,with an aim to provide a theoretical basis for personalized treatment of liposarcoma,promote the development of novel immunotherapy strategies,and ultimately improve patient prognosis and quality of life.

关 键 词：脂肪肉瘤 免疫治疗 肿瘤免疫微环境 免疫逃逸 免疫检查点抑制剂 个体化治疗 

分 类 号：R73[医药卫生—肿瘤]