非编码RNA在结直肠癌中的研究进展及其在早期诊断中的应用  

Progress in research of non-coding RNAs in colorectal cancer and their application in early diagnosis

作　　者：周锦航 蔡成[2] 周晓峰 许丹 Jin-Hang Zhou;Cheng Cai;Xiao-Feng Zhou;Dan Xu(People’s Hospital of Wucheng District,Jinhua City,Jinhua 321000,Zhejiang Province,China;Department of Colorectal and Anal Surgery,Jinhua Central Hospital,Jinhua 321000,Zhejiang Province,China)

机构地区：[1]金华市婺城区人民医院,浙江省金华市321000 [2]金华市中心医院,浙江省金华市321000

出　　处：《世界华人消化杂志》2025年第2期96-105,共10页World Chinese Journal of Digestology

摘　　要：结直肠癌是全球范围内常见的消化系统恶性肿瘤之一,其发病率和死亡率均位居各类疾病的前列.尽管结直肠癌的诊断和治疗技术在近年来取得了一定的进展,现有的诊断手段和治疗方法仍然存在诸多局限,严重影响了结直肠癌的早期发现、精确诊断和个性化治疗.随着分子生物学研究的深入,非编码RNA(non-coding RNA,ncRNA)在结直肠癌的发生、发展和预后评估中越来越受到重视.本文总结了一些结直肠癌与不同类型ncRNA表达相关的研究,并从中挑选了部分有望作为新的肠道肿瘤诊断指标的ncRNA.新的生物指标的出现将有助于结直肠癌早期诊断,提早发现甚至预防肠道癌症的发生.Colorectal cancer is one of the common malignant tumors in the digestive system worldwide,with its incidence and mortality rates ranking high among various diseases.Although certain advancements have been achieved in the diagnosis and treatment techniques of colorectal cancer in recent years,the existing diagnostic means and treatment methods still present numerous limitations,significantly influencing the early detection,precise diagnosis,and individualized treatment of colorectal cancer.With the in-depth research of molecular biology,non-coding RNAs(ncRNAs)have gained increasing attention in the development and prognosis evaluation of colorectal cancer.This paper summarizes some studies related to the expression of different types of ncRNAs in colorectal cancer and selects a portion of ncRNAs that are expected to serve as new diagnostic indicators for this malignancy.The emergence of new biological indicators will contribute to the early diagnosis of colorectal cancer,facilitating its early detection and even prevention.

关 键 词：结直肠癌 微小RNA 环状RNA 长链非编码RNA 

分 类 号：R73[医药卫生—肿瘤]