骨髓间充质干细胞移植治疗肝硬化的研究进展  

Bone marrow mesenchymal stem cell transplantation for treatment of liver cirrhosis:Recent advances

作　　者：阮梦凡 尹宇航 邵晓冬 祁兴顺 Meng-Fan Ruan;Yu-Hang Yin;Xiao-Dong Shao;Xing-Shun Qi(Department of Gastroenterology,General Hospital of Northern Theater Command(Teaching Hospital of Jinzhou Medical University),Shenyang 110840,Liaoning Province,China;Postgraduate College,Jinzhou Medical University,Jinzhou 121001,Liaoning Province,China;Postgraduate College,China Medical University,Shenyang 110122,Liaoning Province,China)

机构地区：[1]北部战区总医院消化内科(锦州医科大学附属教学医院),辽宁省沈阳市110840 [2]锦州医科大学研究生院,辽宁省锦州市121001 [3]中国医科大学研究生院,辽宁省沈阳市110840

出　　处：《世界华人消化杂志》2025年第2期106-113,共8页World Chinese Journal of Digestology

基　　金：辽宁省应用基础研究计划联合计划项目,No.2022JH2/101500032.

摘　　要：肝硬化的发病率和死亡率逐年上升,已成为威胁人类健康的重要因素.肝硬化早期常缺乏明显症状,随着疾病的发展,肝移植已成为肝硬化终末期阶段唯一有效的治疗方法.然而,由于肝移植手术成本高、并发症多且供体资源有限,导致肝移植手术的应用范围受限.目前,干细胞疗法已发展成为治疗肝硬化的一种替代方法.干细胞的来源及类型不一,自体骨髓来源的间充质干细胞(bone marrow mesenchymal stem cells,BMSCs)因其分化潜力大、含量丰富、易于获取和制备等优势已成为参与组织再生的重要细胞之一.本文通过回顾相关文献,对BMSCs治疗肝硬化的机制、移植途径、安全性、有效性、细胞来源、优势及其局限性作一综述.The incidence and mortality of cirrhosis have been increasing year by year,making it become an important factor threatening human health.Cirrhosis in the early stage often lacks obvious symptoms,and liver transplantation has become the only effective treatment for end-stage cirrhosis.However,due to the high cost of liver transplantation,the high incidence of complications,and limited donor resources,the application of liver transplantation has been limited.Currently,stem cell therapy has been considered an alternative treatment for cirrhosis.The sources and types of stem cells are diverse,and autologous bone marrow mesenchymal stem cells(BMSCs)have become one of the important cell types involved in tissue regeneration due to their great differentiation potential,abundant content,and ease of obtaining and preparation.This review summarizes the mechanisms,transplantation routes,safety,effectiveness,cell origin,advantages,and limitations of BMSCs in the treatment of cirrhosis by reviewing the relevant literature.

关 键 词：骨髓间充质干细胞 再生 细胞治疗 肝硬化 干细胞移植 

分 类 号：R575.2[医药卫生—消化系统]