器官芯片及其在新药研发中的应用研究进展  

Research progress in organ-on-a-chip and its application in the development of new drugs

作　　者：张士龙 乐乐 梁徐睿 张晓蔚 左志强 张涛 ZHANG Shi-long;LE Le;LIANG Xu-rui;ZHANG Xiao-wei;ZUO Zhi-qiang;ZHANG Tao(Department of Nuclear Pharmaceutics,School of Pharmacy,Nanjing Medical University,Nanjing 211166,China;Clinical Transformation Center of Nuclear Medicine,Nanjing Medical University,Nanjing 210029,China;National Key Laboratory of Digital Medical Engineering,School of Biological Sciences and Medical Engineering,Southeast University,Nanjing 210000,China)

机构地区：[1]南京医科大学药学院核药学系,南京211166 [2]南京医科大学核医药临床转化中心,南京210029 [3]东南大学生物科学与医学工程学院,数字医学工程全国重点实验室,南京210000

出　　处：《中国新药杂志》2025年第4期386-393,共8页Chinese Journal of New Drugs

基　　金：国家自然科学基金资助项目(12275135);江苏省高等学校大学生创新创业训练计划项目(202310312075Y)。

摘　　要：传统的新药研发具有周期长、耗资大、失败率高等问题。为了克服上述问题,器官芯片技术应运而生,作为近年来新兴的前沿技术,在新药研发过程中发挥巨大作用。本文重点阐述了器官芯片在新药研发中的应用及其在核药研发领域中的潜在应用,并讨论了器官芯片所面临的机遇与挑战,为新药研发工作者提供参考和借鉴。Traditional new drug research and development(R&D)has problems such as long period,high cost,and high failure rate.In order to overcome the above problems,organ-on-a-chip technology comes into being,which plays a huge role in the R&D of new drugs as an emerging frontier technology in recent years.This article focuses on the application of organ-on-a-chip in the R&D of new drugs and its potential applications in the field of nuclear drug R&D,and discusses the opportunities and challenges faced by organ-on-chip,so as to provide references for new drug R&D practitioners.

关 键 词：器官芯片 新药研发 药物发现 疾病模型 核素药物 

分 类 号：R91[医药卫生—药学]