雷贝拉唑联合升阳益胃汤治疗慢性萎缩性胃炎癌前病变的效果  

Effect of Rabeprazole Combined with Shengyang Yiwei Decoction in the Treatment of Precancerous Lesions of Chronic Atrophic Gastritis

作　　者：董一 李媛媛 任文 DONG Yi;LI Yuanyuan;REN Wen(Department of Traditional Chinese Medicine,Jiaozhou Central Hospital of Qingdao,Jiaozhou 266300,Shandong,China)

机构地区：[1]青岛市胶州中心医院中医科,山东胶州266300

出　　处：《世界复合医学(中英文)》2024年第10期70-73,共4页World Journal of Complex Medicine

摘　　要：目的 探究雷贝拉唑与升阳益胃汤治疗慢性萎缩性胃炎癌前病变的效果。方法 选取2022年8月—2023年7月于青岛市胶州中心医院治疗的慢性萎缩性胃炎癌前病变患者120例,按治疗方法不同分为两组,对照组(60例)给予雷贝拉唑治疗,观察组(60例)在对照组基础上加用升阳益胃汤治疗。对比两组临床疗效、中医证候积分、不良反应发生情况、胃泌素、胃蛋白酶原Ⅰ、胃蛋白酶原Ⅱ水平。结果 观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组胃功能指标水平均高于对照组,中医证候积分均低于对照组,差异有统计学意义(P均<0.05)。观察组治疗总有效率为98.33%(59/60),高于对照组的83.33%(50/60),差异有统计学意义(χ^(2)=8.339,P<0.05)。结论 雷贝拉唑联合升阳益胃汤治疗慢性萎缩性胃炎癌前病变效果显著,安全性较高。Objective To explore the effect of rabeprazole and Shengyang Yiwei Decoction in the treatment of precancerous lesions of chronic atrophic gastritis.Methods A total of 120 patients with precancerous lesions of chronic atrophic gastritis treated in Jiaozhou Central Hospital of Qingdao from August 2022 to July 2023 were selected and divided into two groups according to different treatment methods.The control group(60 cases) was treated with rabeprazole,and the observation group(60 cases) was treated with Shengyang Yiwei Decoction on the basis of the control group.The clinical efficacy,traditional Chinese medicine symptom scores,adverse reactions,gastrin,pepsinogen I,pepsinogen Ⅱ levels were compared between the two groups.Results The incidence of adverse reactions in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).After treatment,the levels of gastric function indexes were higher than those in the control group,andthe traditional Chinese medicine symptom scores of the observation group were lower than those of the control group,the differences were statistically significant(all P<0.05).The total effective rate of treatment in the observation group was 98.33%(59/60),which was higher than 83.33%(50/60) in the control group,and the difference was statistically significant(χ~2=8.339,P<0.05).Conclusion Rabeprazole combined with Shengyang Yiwei Decoction is effective and safe in the treatment of precancerous lesions of chronic atrophic gastritis.

关 键 词：雷贝拉唑 升阳益胃汤 联合治疗 慢性萎缩性胃炎癌前病变 

分 类 号：R573.32[医药卫生—消化系统]