阴道镜辅助下LEEP刀手术治疗子宫颈高级别癌前期病变的临床有效性及安全性分析  

Clinical Efficacy and Safety of Colposcopy Combined with LEEP in the Treatment of Highgrade Cervical Precancerous Lesions

作　　者：王志萍 黎云 WANG Zhiping;LI Yun(Department of Gynecology,Qingyang People's Hospital,Qingyang 745000,Gansu,China)

机构地区：[1]庆阳市人民医院妇科,甘肃庆阳745000

出　　处：《世界复合医学(中英文)》2024年第10期98-101,共4页World Journal of Complex Medicine

摘　　要：目的 探讨阴道镜辅助下LEEP刀手术治疗子宫颈高级别癌前期病变患者的有效性及安全性。方法 选取2021年1月—2022年6月庆阳市人民医院妇科收治的70例子宫颈高级别癌前期病变患者为研究对象,以不同手术方案将患者分为观察组和对照组,各35例。对照组应用常规外科手术治疗,观察组应用阴道镜+LEEP刀方案治疗。对比两组患者临床疗效、手术时间、术中出血量、住院时间、并发症发生率、复发率、二次手术率和人类乳头状瘤病毒(high risk human papilloma virus,HR-HPV)转阴率。结果 观察组治疗有效率为97.14%(34/35),高于对照组的80.00%(28/35),差异有统计学意义(χ^(2)=5.081,P<0.05)。观察组手术时间、术中出血量、住院时间、二次手术率、HR-HPV转阴率均优于对照组,差异有统计学意义(P均<0.05)。两组复发率比较,差异无统计学意义(P>0.05)。观察组并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论 子宫颈高级别癌前期病变采用阴道镜结合LEEP刀手术方案进行干预,疗效显著,安全性较高。Objective To investigate the efficacy and safety of vaginal assisted LEEP knife in the treatment of patients with high-grade cervical precancerous lesions.Methods A total of 70 patients with high-grade cervical precancerous lesions admitted to the Department of Gynecology in Qingyang People's Hospital from January 2021 to June 2022 were selected as the research objects.The patients were divided into observation group and control group according to different surgical schemes,with 35 cases in each group.The control group was treated with conventional surgical treatment,and the observation group was treated with colposcopy+LEEP knife.The clinical efficacy,operation time,intraoperative blood loss,hospitalization time,complication rate,recurrence rate,secondary operation rate and negative conversion rate of high risk human papilloma virus(HRHPV) were compared between the two groups.Results The effective rate of treatment in the observation group was 97.14%(34/35),which was higher than 80.00%(28/35) of the control group,and the difference was statistically significant(χ~2=5.081,P<0.05).The operation time,intraoperative blood loss,hospitalization time,secondary operation rate and HR-HPV negative conversion rate in the observation group were better than those in the control group,and the differences were statistically significant(all P<0.05).There was no significant difference in the recurrence rate between the two groups(P>0.05).The incidence of complications in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion Colposcopy combined with LEEP knife surgery is effective and safe in the treatment of high-grade cervical precancerous lesions.

关 键 词：阴道镜 LEEP刀 手术治疗方案 宫颈高级别癌前期病变 

分 类 号：R731[医药卫生—肿瘤]