奥美拉唑静脉给药联合消化内镜治疗消化性溃疡出血的应用效果分析  

Application Effect of Omeprazde Intravenous Administration Combined with Digestive Endoscopy in the Treatment of Peptic Ulcer Hemorrhage

作　　者：刘俊 邢朝富 张德平 LIU Jun;XING Chaofu;ZHANG Deping(Department of Gastroenterology,Dantu District People's Hospital,Zhenjiang 212000,Jiangsu,China)

机构地区：[1]江苏省镇江市丹徒区人民医院消化内科,江苏镇江212000

出　　处：《世界复合医学(中英文)》2024年第10期123-127,共5页World Journal of Complex Medicine

摘　　要：目的 探究奥美拉唑静脉给药联合消化内镜治疗消化性溃疡出血的应用效果。方法 选取2021年1月—2023年6月江苏省镇江市丹徒区人民医院消化内科收治的60例消化性溃疡出血患者为研究对象,根据不同的治疗方法分为对照组(予以奥美拉唑静脉给药治疗)、观察组(予以奥美拉唑静脉给药联合消化内镜治疗),各30例。比较两组止血成功率、胃黏膜功能(胃蛋白酶原I、胃蛋白酶原Ⅱ、胃泌素17)、临床总有效率、病情恢复情况、不良反应发生率。结果 观察组止血成功率为96.67%(29/30),高于对照组的73.33%(22/30),差异有统计学意义(χ^(2)=4.706,P<0.05)。观察组治疗总有效率高于对照组,,差异有统计学意义(P<0.05)。观察组胃蛋白酶原I、胃蛋白酶原Ⅱ均低于对照组,胃泌素17高于对照组,差异有统计学意义(P均<0.05)。观察组出血量、输血量均少于对照组,止血时间、住院天数均短于对照组,差异有统计学意义(P均<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 奥美拉唑静脉给药结合消化内镜的临床疗效确切,安全性高,有助于改善消化性溃疡出血患者胃黏膜功能,提高止血成功率。Objective To explore the application effect of omeprazole intravenous administration combined with digestive endoscopy in the treatment of peptic ulcer hemorrhage.Methods From January 2021 to June 2023,60 patients with peptic ulcer hemorrhage admitted to the Department of Gastroenterology in Dantu District People 's Hospital of Zhenjiang City of Jiangsu Province were selected as the research objects.According to different treatment methods,they were divided into control group(omeprazole intravenous administration) and observation group(omeprazole intravenous administration combined with digestive endoscopy),30 cases in each group.The success rate of hemostasis,gastric mucosal function(pepsinogen Ⅰ,pepsinogen Ⅱ,gastrin-17),clinical total effective rate,recovery of disease and incidence of adverse reactions were compared between the two groups.Results The success rate of hemostasis in the observation group was 96.67%(29/30),which was higher than 73.33%(22/30) in the control group,the difference was statistically significant(χ~2=4.706,P<0.05).The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Pepsinogen I and pepsinogen Ⅱ in the observation group were lower than those in the control group,and gastrin-17 was higher than that in the control group,the differences were statistically significant(all P<0.05).The amount of bleeding and blood transfusion in the observation group were less than those in the control group,and the hemostasis time and hospitalization days were shorter than those in the control group,the differences were statistically significant(all P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The clinical efficacy of omeprazole intravenous administration combined with digestive endoscopy was accurate and safe,which was helpful to improved the gastric mucosal function of patients with peptic ulcer hemorrhage and improve the

关 键 词：消化性溃疡出血 奥美拉唑 消化内镜 止血成功率 

分 类 号：R573.1[医药卫生—消化系统]