经颅交流电刺激治疗Alzheimer’s病的研究进展  

Research progress of transcranial alternating current stimulation in the treatment of Alzheimer’s disease

作　　者：方双 璩龙杰 徐运[1] 朱晓蕾[1] FANG shuang;QU Longjie;XU Yun(Drum Tower Clinical Medical College Affiliated to Nanjing Medical University,Nanjing 210008,China)

机构地区：[1]南京医科大学附属鼓楼临床医学院,210008

出　　处：《临床神经病学杂志》2025年第1期65-69,共5页Journal of Clinical Neurology

基　　金：江苏省自然科学基金项目(BK20231120);南京市卫生科技发展重点项目(ZKX22025)。

摘　　要：Alzheimer’s病(AD)是导致老年性痴呆最常见的神经退行性疾病,其特点是认知功能和日常生活能力的逐渐下降。AD的发病机制尚不清楚,且现有的药物治疗效果有限,因此寻找新的治疗方法至关重要。现有研究显示,经颅交流电刺激(tACS)能够改善AD认知功能障碍,可能与tACS能通过调节单一或嵌套脑节律、局部或远端脑网络神经活动同步以及代谢活动来影响认知功能有关。本文综述了tACS治疗AD的研究进展,以期为探索AD的发病机制和治疗提供新的思路。Alzheimer’s disease(AD)is the most common neurodegenerative disorder leading to dementia in the elderly,characterized by a gradual decline in cognitive function and daily living abilities.The pathogenesis of AD remains unclear,and the efficacy of existing pharmacological treatments is limited,making the search for new therapeutic approaches imperative.Current research suggests that transcranial alternating current stimulation(tACS)can ameliorate cognitive deficits in AD,potentially due to its ability to modulate single or nested brain rhythms,local or distant synchronization,and metabolic activity,which can influence cognitive functions.This review summarizes the research progress of tACS in the treatment of AD,aiming to provide new insights into the exploration of the pathogenesis and treatment of AD.

关 键 词：Alzheimer’s病 经颅交流电刺激 认知和记忆功能 精神症状 睡眠质量 

分 类 号：R749.1[医药卫生—神经病学与精神病学]