农用抗生素的毒代动力学研究进展  

Advances in Toxicokinetics of Agricultural Antibiotics

作　　者：杨佳音 李鸣霄 陈曦 宋超[2,3] 许晶 范立民[2,3] 裘丽萍[2] 李丹丹[2] 徐慧敏 孟顺龙 穆希岩[5] 夏斌 YANG Jiayin;LI Mingxiao;CHEN Xi;SONG Chao;XU Jing;FAN Limin;QIU Liping;LI Dandan;XU Huimin;MENG Shunlong;MU Xiyan;XIA Bin(College of Fisheries and Life Science,Shanghai Ocean University,Shanghai 200120,China;Freshwater Fisheries Research Center,Chinese Academy of Fishery Sciences,Scientific Observing and Experimental Station of Fishery Resources and Environment in the Lower Reaches of the Yangtze River,Wuxi 214081,China;Wuxi Fishery College,Nanjing Agricultural University,Wuxi 214081,China;Wuxi Environmental Monitoring Center,Wuxi 214081,China;Institute of Quality Standard and Testing Technology for Agro-Products,Chinese Academy of Agricultural Sciences,Beijing 100081,China;Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao 266071,China)

机构地区：[1]上海海洋大学水产与生命学院,上海200120 [2]中国水产科学研究院淡水渔业研究中心,长江下游渔业资源与环境科学观测实验站,无锡214081 [3]南京农业大学无锡渔业学院,无锡214081 [4]无锡市环境监测中心,无锡214081 [5]中国农业科学院农业质量标准与检测技术研究所,北京100081 [6]中国水产科学研究院黄海水产研究所,青岛266071

出　　处：《生态毒理学报》2025年第1期280-294,共15页Asian Journal of Ecotoxicology

基　　金：财政部和农业农村部国家现代农业产业技术体系(CARS-46);中国水产科学研究院基本科研业务费:长江渔业生态环境监测与修复创新团队项目(2024TD18)。

摘　　要：近年来,持久性有机污染物、内分泌干扰物、抗生素和微塑料被列为四大新污染物。它们具有生物毒性、环境持久性和生物累积性,在环境中的残留和迁移会对生态环境乃至人体产生长久危害。我国是农业大国,在种植、养殖业生产中滥用农药和兽药的现象层出不穷,导致环境中有农用抗生素污染物残留。因此,研究这类农用抗生素新污染物在机体内的毒代动力学及影响因素可以为药物使用风险评估、残留评估提供基础数据,为毒理学和生态环境领域的研究奠定基础。本文综述了毒代动力学和其应用于农用抗生素的案例及影响毒代(药代)动力学因素的研究进展,以期为农用抗生素的毒代动力学研究提供参考。In recent years,persistent organic pollutants,endocrine disruptors,antibiotics,and microplastics have been identified as four major types of emerging pollutants.These substances are characterized by their biological toxicity,environmental persistence,and bioaccumulative properties.Their residues and migration in the environment can cause long-term harm to ecosystems and human health.As a major agricultural country,China faces widespread use of pesticides and veterinary drugs in crop cultivation and animal husbandry,resulting in residual agricultural antibiotic pollutants in the environment.Therefore,studying the toxicokinetics and influencing factors of these agricultural antibiotic pollutants in organisms can provide fundamental data for drug use risk assessment and residue evaluation,laying a foundation for research in toxicology and environmental science.This article reviews the progress in toxicokinetics research,its application to agricultural antibiotics,and factors affecting toxicokinetics(pharmacokinetics),aiming to provide a reference for toxicokinetic studies of agricultural antibiotics.

关 键 词：农用抗生素 毒代动力学 风险评估 

分 类 号：X171.5[环境科学与工程—环境科学]