胆管反应在原发性硬化性胆管炎进展中的作用及其靶向治疗现状  

Recent advances in ductular reaction in the context of primary sclerosing cholangitis:mechanistic insights and targeted therapy

作　　者：崔一鸣 胡博 林浩婷 王佳敏 洪健 陶萍 CUI Yiming;HU Bo;LIN Haoting;WANG Jiamin;HONG Jian;TAO Ping(Department of Pathophysiology,Key Laboratory of State Administration of Traditional Chinese Medicine,School of Medi-cine,Jinan University,Guangzhou 510632;Institute of Chinese Materia Medica,Jinan University,Guangzhou 510632;The First Affiliated Hospital of Jinan University,Guangzhou 510632,China)

机构地区：[1]暨南大学基础医学与公共卫生学院病理生理学系,国家中医药管理局病理生理学重点实验室,广东广州510632 [2]生物活性分子与成药性优化全国重点实验室,广东广州510632 [3]暨南大学附属第一医院,广东广州510632

出　　处：《中国病理生理杂志》2025年第2期369-375,共7页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金面上项目(No.82473023);广东省基础与应用基础研究基金面上项目(No.2023A1515012905)。

摘　　要：原发性硬化性胆管炎(primary sclerosing cholangitis,PSC)是以多灶性胆管狭窄和进行性肝病为特征的自身免疫性疾病,发病机制尚不明确。胆管反应是PSC的核心病理表现,亦是促进PSC进展的关键因素。本文旨在从胆管细胞增殖、炎症应答、纤维化形成等多维角度,就胆管反应在PSC进展中的促进作用及其靶向治疗作一综述,为揭示PSC的病理机制和寻找新的治疗策略提供理论依据。Primary sclerosing cholangitis(PSC)is an autoimmune disease characterized by chronic inflammation and progressive fibrosis that affects both intrahepatic and extrahepatic bile ducts.Despite ongoing research,the underlying mechanisms of PSC pathogenesis remain incompletely understood.The ductular reaction is not only a key pathological feature of PSC but also serves as a driving force in its progression.This review examines the promoting effects of the ductular reaction on PSC advancement from multiple perspectives,including the proliferation of biliary epithelial cells,inflammation,and fibrosis.By providing theoretical insights into the pathogenesis of PSC,this review aims to facilitate the identification of novel therapeutic strategies.

关 键 词：原发性硬化性胆管炎 胆管反应 炎症 纤维化 

分 类 号：R575.7[医药卫生—消化系统] R657.45[医药卫生—内科学] R363[医药卫生—临床医学]