人乳头瘤病毒与头颈部鳞癌肿瘤免疫微环境相互作用的研究进展  

Progress in interplay between human papillomavirus and tumor immune microenvironment of head and neck squamous cell carcinoma

作　　者：张凌楠 周思远 刘晓燕 王晶[4] Zhang Lingnan;Zhou Siyuan;Liu Xiaoyan;Wang Jing(Department of Orthodontics,Binzhou Medical University Hospital,Binzhou 256600,China;Department of Oral and Maxillofacial Surgery,Binzhou Medical University,Binzhou 256600,China;School of Stomatology,Binzhou Medical University,Yantai 264000,China;Department of Oral Medicine,Binzhou Medical University Hospital,Binzhou 256600,China)

机构地区：[1]滨州医学院附属医院口腔正畸科,山东滨州256600 [2]滨州医学院附属医院口腔颌面外科,山东滨州256600 [3]滨州医学院口腔医学院,山东烟台264000 [4]滨州医学院附属医院口腔内科,山东滨州256600

出　　处：《中国病理生理杂志》2025年第2期403-411,共9页Chinese Journal of Pathophysiology

基　　金：山东省自然科学基金博士基金资助项目(No.ZR2018BH026);山东省医药卫生科技发展计划面上项目(No.2017WS231);山东省中医药科技青年项目(No.2020Q062)。

摘　　要：目前,在头颈部鳞状细胞癌(head and neck squamous cell carcinoma,HNSCC)的致病因素中,除了公认的吸烟和过量饮酒之外,高危型人乳头瘤病毒(human papillomavirus,HPV)的持续感染日益受到关注,并已被视为一种新兴的独立致病要素。HPV相关的HNSCC不仅具有预后良好的独特临床特点,而且其与肿瘤免疫微环境的紧密互动,已成为当前研究的热点话题。HPV及其诱发的肿瘤免疫微环境在HNSCC的发病、进展、治疗及转归过程中发挥着至关重要的作用。本文旨在综述HPV阳性HNSCC的免疫逃逸机制,探讨HPV对肿瘤免疫微环境的影响,以及其与宿主适应性免疫之间的相互作用。另外,本文将分析特异性免疫反应在改善HPV相关HNSCC预后方面的潜在价值,并评估免疫分析在预后预测中的潜在应用。此外,我们将针对性地讨论HPV相关HNSCC的新兴免疫治疗方法和策略,以期促进针对HPV靶点的肿瘤免疫治疗在HNSCC,特别是免疫反应活跃的口咽鳞状细胞癌中的临床应用,为相关领域的研究和实践提供参考和借鉴。Head and neck squamous cell carcinoma(HNSCC)is currently acknowledged as an independent cause of disease.Beyond smoking and heavy alcohol use,persistent infection with high-risk human papillomavirus(HPV)is receiving increased recognition as a newly identified independent cause of this condition.The distinct clinical characteristics of HPV-related HNSCC,which are linked with a better prognosis,and its interaction with the tumor immune microenvironment,are areas of intense research focus.The specific immune response triggered by HPV and the tumor immune microenvironment are vital in the development,progression,and outcome of HNSCC.This review examines the ways HPV positive HNSCC evades the immune system,assesses the influence of HPV on the tumor immune microenvironment in HNSCC,and explores its interaction with the body's adaptive immunity.This article presents a review on the evaluation of specific immune responses in improving the prognosis of HPV-related HNSCC and discusses the potential value of immune analysis in predicting prognosis.Furthermore,we analyze novel immune therapy strategies,mechanisms,and prognosis in HPV-related HNSCC.

关 键 词：人乳头瘤病毒 头颈部鳞状细胞癌 肿瘤免疫微环境 免疫治疗 预后 

分 类 号：R739.8[医药卫生—肿瘤] R457.2[医药卫生—临床医学] R363