分泌蛋白Dickkopf家族在结直肠癌中的研究进展  

Research progress of Dickkopf family in colorectal cancer

作　　者：方云 王应辉 周响 FANG Yun;WANG Yinghui;ZHOU Xiang(Guiyang Second People's Hospital,Guiyang 550000,China;Department of Clinical Laboratory,Guizhou Qiannan Peo-ple's Hospital,Duyun 558000,China;The Affiliated Hospital of Guizhou Medical University,Guiyang 550001,China)

机构地区：[1]贵阳市第二人民医院,贵州贵阳550000 [2]贵州省黔南州人民医院医学检验科,贵州都匀558000 [3]贵州医科大学附属医院,贵州贵阳550001

出　　处：《中国病理生理杂志》2025年第2期412-416,共5页Chinese Journal of Pathophysiology

基　　金：贵州省卫生健康委科学技术基金项目(No.gzwkj2024-467)。

摘　　要：结直肠癌(colorectal cancer,CRC)是目前第三大最常见的肿瘤,也是肿瘤相关死亡率的第二大原因。Wnt/β-catenin信号通路异常是导致CRC发生发展的关键信号通路之一。Dickkopf家族由分泌蛋白组成,作为该信号通路的拮抗剂,显著影响CRC的进展。该家族包括Dickkopf-1~Dickkopf-4,每个成员在CRC中表现出不同的作用。本文就分泌型Dickkopf家族在CRC中的作用的研究进展作出综述。Colorectal cancer(CRC)is currently the third most prevalent tumor and the second leading cause of cancer-related mortality.Abnormal Wnt/β-catenin signaling pathway is one of the key signaling pathways leading to the occurrence and development of CRC.The Dickkopf family,consisting of secreted proteins,acts as antagonists to this signaling pathway and significantly influences the progression of CRC.The family includes Dickkopf-1 to Dickkopf-4 secreted proteins,with each member exhibiting distinct roles in the context of CRC.This article aimed to provide a comprehensive overview of the research advancements concerning the secreted Dickkopf family's role in CRC.

关 键 词：Dickkopf蛋白 结直肠癌 WNT/Β-CATENIN信号通路 

分 类 号：R363.2[医药卫生—病理学] R735.3[医药卫生—基础医学] R730.23