基于“肝与大肠相通”探讨从肠道菌群论治自身免疫性肝病  

Exploring the treatment of autoimmune liver disease from the perspective of gut microbiota based on the concept of"liver and large intestine interconnection"

作　　者：孙岩 吕冠华 范颖[1] SUN Yan;LYU Guan-hua;FAN Ying(Second Clinical College,Liaoning University of Traditional Chinese Medicine(Shenyang Liaoning,110034),China)

机构地区：[1]辽宁中医药大学第二临床学院,辽宁沈阳110034 [2]辽宁中医药大学附属第二医院

出　　处：《中西医结合肝病杂志》2025年第2期234-237,共4页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：辽宁省中医药管理局辽宁省名中医传承工作室建设项目(辽中医药发[2022]1号)。

摘　　要：自身免疫性肝病(AILD)是一类自身免疫介导的疾病,其发病机制至今尚未明确。“肝与大肠相通”理论最早由明代李梃提出,此理论为后世医家治疗肝病提供了思路。从肝与大肠经络循行、功能互用、五行相克等角度探讨了两者的生理联系,并阐明该病病机为肝肠气机失调、肠闭浊气积聚。基于现代医学“肠-肝轴”理论探讨肠道菌群与AILD发病的联系,并从肠道菌群论治AILD,以期为指导AILD用药拓宽思路。Autoimmune liver disease(AILD)is an autoimmune-mediated condition,and its pathogenesis remains unclear.The theory of"the liver and large intestine are interconnected"was first proposed by Li Ting in the Ming Dynasty,which has provided insights for subsequent generations of physicians in treating liver diseases.This article discusses the physiological connection between the liver and large intestine from the perspectives of their meridian circulation,functional interdependence,and the Five Elements theory.It explains that the pathogenesis of AILD involves the imbalance of liver and intestinal qi and the accumulation of stagnant dampness and turbidity in the intestines.Based on the modern"gut-liver axis"theory,the relationship between gut microbiota and the development of AILD is explored,and treatment strategies targeting the gut microbiota are discussed,aiming to broaden the therapeutic approach for AILD.

关 键 词：自身免疫性肝病 “肝与大肠相通”理论 肠道菌群 

分 类 号：R575[医药卫生—消化系统] R256.4[医药卫生—内科学]