中医药调控Notch信号通路治疗肝纤维化的研究概况  

General situation of research on notch signaling pathway regulated by traditional Chinese medicine in the treatment of hepatic fibrosis

作　　者：陈东方 郑丽红[2] CHEN Dong-fang;ZHENG Li-hong(Graduate School of Heilongjiang University of Chinese Medicine,(Harbin Heilongjiang,150040),China)

机构地区：[1]黑龙江中医药大学研究生院,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第四医院消化内科

出　　处：《中西医结合肝病杂志》2025年第2期260-264,共5页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：黑龙江省卫生健康委科技计划项目(No.20222121021005);黑龙江省中医药管理局项目(No.ZHY2022-205)。

摘　　要：肝纤维化是多种慢性肝病的潜在病理阶段,若得不到有效的治疗,最终有发展成为肝硬化、肝癌的风险。Notch信号通路是一条古老且保守的信号通路,对肝纤维化进程中的肝细胞、肝星状细胞及巨噬细胞具有调节作用。中医药作为我国特色的治疗方法,对肝纤维化具有独特的治疗优势。已有研究表明,中医药可以干预Notch信号通路的表达,从而抑制炎症反应、减少纤维成分的沉积,缓解肝纤维化的进展。本文章介绍了Notch信号通路的结构及其对肝纤维化进程的影响、中药单体及中医药复方对Notch信号通路的调控,旨在探讨中医药治疗肝纤维化的靶点及应用前景,为进一步的临床研究提供有益的参考。Hepatic fibrosis is a potential pathological stage of many chronic liver diseases.Without effective treatment,it may eventually develop into cirrhosis and liver cancer.Notch signaling pathway is an ancient and conserved signaling pathway that regulates hepatocytes,hepatic stellate cells and macrophages in the process of hepatic fibrosis.Traditional Chinese medicine,as a special treatment method in China,has a unique advantage in the treatment of hepatic fibrosis.Studies have shown that Chinese medicine can interfere with the expression of Notch signaling pathway,thereby inhibiting inflammatory response,reducing the deposition of fiber components,and easing the progression of hepatic fibrosis.This article introduced the structure of Notch signaling pathway and its influence on the progression of hepatic fibrosis,and the regulation of Notch signaling pathway by Chinese medicine monomers and Chinese medicine compounds,aiming to explore the target and application prospect of Chinese medicine in the treatment of liver fibrosis,and provide useful reference for further clinical research.

关 键 词：肝纤维化 NOTCH信号通路 中医药 

分 类 号：R575.2[医药卫生—消化系统]