RNA剪接和剪接因子在动脉粥样硬化发生中的研究进展  

The progress of RNA splicing and splicing factors in the atherogenesis

作　　者：高慧敏 耿彬 GAO Huimin;GENG Bin(Hypertension Center,State Key Laboratory of Cardiovascular Disease&National Center for Cardiovascular Diseases,Fuwai Hospital of Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 102300,China)

机构地区：[1]北京协和医学院中国医学科学院阜外医院高血压中心心血管疾病国家重点实验室国家心血管病中心,北京市102300

出　　处：《中国动脉硬化杂志》2025年第2期93-101,共9页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(82370448)。

摘　　要：RNA剪接是真核生物基因表达调控中的关键过程。选择性剪接使得生物体能够从单一转录本中产生多个功能的RNA和蛋白质,从而极大地扩展了遗传信息的应用,使得少数基因得以表达多种复杂蛋白质成为可能。越来越多的研究表明,错误的剪接事件与多种疾病如心血管疾病的发生和发展有着密切的关系。本综述概述了RNA剪接的定义和机制,以及选择性剪接在动脉粥样硬化发病机制中的作用。RNA splicing is an important process for eukaryotes to regulate gene expression.Alternative splicing allows organisms to produce multiple functional RNAs and proteins from a single transcript,thereby expanding the application of genetic information.Moreover,alternative splicing makes it a reality that limited numbers genes can express numerous complex proteins.More and more studies reveal that incorrect splicing is closely associated with human diseases including cardiovascular diseases.This review provides an overview of the definition and mechanism of RNA splicing,as well as the role of alternative splicing in the pathogenesis of atherosclerosis.

关 键 词：RNA剪接 选择性剪接 剪接因子 动脉粥样硬化 

分 类 号：R363[医药卫生—病理学] R5[医药卫生—基础医学]